Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones

Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2019, Volume: 68, Number: 5, Pages: 1061-1066 Pages count : 6 DOI: 10.1007/s11172-019-2520-5

Tags

monoterpenoids; montmorillonite K10; heterocyclic compounds; analgesic activity

Authors

Il'ina I.V. ^1,2 , Korchagina D.V. ¹ , Morozova E.A. ¹ , Tolstikova T.G. ¹ , Volcho K.P. ^1,2 , Salakhutdinov N.F. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrentieva, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk Natl Res State Univ, 1 Ul Pirogova, Novosibirsk 630090, Russia

A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid ()-isopulegol. A condensation product of ()-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.

Il'ina I.V. , Korchagina D.V. , Morozova E.A. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones
Russian Chemical Bulletin. 2019. V.68. N5. P.1061-1066. DOI: 10.1007/s11172-019-2520-5 WOS Scopus РИНЦ

Ильина И.В. , Корчагина Д.В. , Морозова Е.А. , Толстикова Т.Г. , Волчо К.П. , Салахутдинов Н.Ф.
Синтез и анальгетическая активность октагидро-2H-хроменолов - производных алифатических кетонов
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2019. №5. С.1061-1066. РИНЦ

Published print:	May 1, 2019
Published online:	Jun 11, 2019

Web of science	WOS:000471201700018
Scopus	2-s2.0-85067041253
Elibrary	41622327
OpenAlex	W2951394690