3-Carboxy-2,2,5,5-tetra(H-2(3))methyl-[4-H-2 (H-1)]-3-pyrroline-(1-N-15)-1-oxyl as a spin probe for in vivo L-band electron paramagnetic resonance imaging

3-Carboxy-2,2,5,5-tetra(H-2(3))methyl-[4-H-2 (H-1)]-3-pyrroline-(1-N-15)-1-oxyl as a spin probe for in vivo L-band electron paramagnetic resonance imaging Full article

Journal

Mendeleev Communications
ISSN: 0959-9436

Output data

Year: 2014, Volume: 24, Number: 5, Pages: 298-300 Pages count : DOI: 10.1016/j.mencom.2014.09.017

Authors

Shundrin Leonid A. ^1,2,3 , Kirilyuk Igor A. ^1,2 , Grigor'ev Igor A. ^1,4

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia
3	(Данные Web of science) Sci Inst Clin & Expt Lymphol, Novosibirsk 630060, Russia
4	(Данные Web of science) EN Meshalkin State Res Inst Circulat Pathol, Novosibirsk 630055, Russia

The suitability of 3-Carboxy-2,2,5,5-tetra(H-2(3))methyl-[4-H-2 (H-1)]-3-pyrroline-(1-N-15)-1-oxyl and its non-deuterated N-14-containing nitroxide analogue for L-band EPR in vivo imaging has been demonstrated. Both nitroxides exhibit low rates of reduction with ascorbate and slow decay in mice blood and plasma and, according to the EPR data, accumulate in the liver of a living mice within 10-70 min after the injection via tail vein, and then collect in the bladder.

Shundrin L.A. , Kirilyuk I.A. , Grigor'ev I.A.
3-Carboxy-2,2,5,5-tetra(H-2(3))methyl-[4-H-2 (H-1)]-3-pyrroline-(1-N-15)-1-oxyl as a spin probe for in vivo L-band electron paramagnetic resonance imaging
Mendeleev Communications. 2014. V.24. N5. P.298-300. DOI: 10.1016/j.mencom.2014.09.017 WOS Scopus РИНЦ

Published print:

Sep 1, 2014

Web of science	WOS:000344137100017
Scopus	2-s2.0-84908570716
Elibrary	23997904
OpenAlex	W2029676086