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Synthesis of 4,5-Dialkyl-2-perfluoroaryl-1H-imidazol-1-ols and 4,5-Dimethyl-2-perfluoroaryl-1H-imidazoles Full article

Journal Russian Journal of Organic Chemistry
ISSN: 1070-4280 , E-ISSN: 1608-3393
Output data Year: 2021, Volume: 57, Number: 12, Pages: 1968-1973 Pages count : 6 DOI: 10.1134/S1070428021120101
Tags 1-hydroxy-1H-imidazoles; 1H-imidazoles; aliphatic α-hydroxyamino oximes; chloroacetone; condensation; perfluoroaromatic aldehydes
Authors Os’kina I.A. 1 , Vinogradov A.S. 1 , Selivanov B.A. 1 , Savelyev V.A. 1 , Platonov V.E. 1 , Tikhonov A.Ya. 1
Affiliations
1 Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

Abstract: Aliphatic α-hydroxyamino oximes reacted with perfluoroaromatic aldehydes to give α-perfluoroaryl nitrones which underwent cyclization in acetic acid with the formation of 4,5-dialkyl-2-perfluoroaryl-1H-imidazol-1-ols. The latter were also obtained directly from aliphatic α-hydroxyamino oximes and perfluoro­aromatic aldehydes in acetic acid without isolation of intermediate nitrones. The reaction of 4,5-dimethyl-2-perfluoroaryl-1H-imidazol-1-ols with chloroacetone afforded 4,5-dimethyl-2-perfluoroaryl-1H-imidazoles.
Cite: Os’kina I.A. , Vinogradov A.S. , Selivanov B.A. , Savelyev V.A. , Platonov V.E. , Tikhonov A.Y.
Synthesis of 4,5-Dialkyl-2-perfluoroaryl-1H-imidazol-1-ols and 4,5-Dimethyl-2-perfluoroaryl-1H-imidazoles
Russian Journal of Organic Chemistry. 2021. V.57. N12. P.1968-1973. DOI: 10.1134/S1070428021120101 WOS Scopus РИНЦ
ArticleLinkType.TRANSLATED_TO_ORIGINAL: Оськина И.А. , Виноградов А.С. , Селиванов Б.А. , Савельев В.А. , Платонов В.Е. , Тихонов А.Я.
Синтез 4,5-диалкил-2-перфторарил-1H-имидазол-1-олов и 4,5-диметил-2-перфторарил-1H-имидазолов
Журнал органической химии (RUSS J ORG CHEM+). 2021. Т.57. №12. С.1752-1758. DOI: 10.31857/S0514749221120107 РИНЦ
Dates:
Submitted: Jun 30, 2021
Accepted: Jul 14, 2021
Published print: Jan 17, 2022
Identifiers:
Web of science WOS:000743535900010
Scopus 2-s2.0-85123081685
Elibrary 48129904
OpenAlex W4206245063
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