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Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles Full article

Journal Molecules
, E-ISSN: 1420-3049
Output data Year: 2022, Volume: 27, Number: 15, Article number : 4761, Pages count : 21 DOI: 10.3390/molecules27154761
Tags monoterpenoids; monoterpenes; vaccinia virus; Marburg virus; heterocyclic compounds
Authors Oreshko Vladislav V. 1,2 , Kovaleva Kseniya S. 1 , Mordvinova Ekaterina D. 2,3 , Yarovaya Olga I. 1,2 , Gatilov Yuri V. 1 , Shcherbakov Dmitry N. 3 , Bormotov Nikolai I. 3 , Serova Olga A. 3 , Shishkina Larisa N. 3 , Salakhutdinov Nariman F. 1
Affiliations
1 Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia
2 Zelman Institute for Medicine and Psychology, Novosibirsk State University, Pirogova St., 1, 630090 Novosibirsk, Russia
3 State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia

Abstract: A set of heterocyclic products was synthesized from natural (+)-camphor and semi-synthetic (−)-camphor. Then, 2-Imino-4-thiazolidinones and 2,3-dihydrothiazoles were obtained using a three-step procedure. For the synthesized compounds, their antiviral activity against the vaccinia virus and Marburg virus was studied. New promising agents active against both viruses were found among the tested compounds.
Cite: Oreshko V.V. , Kovaleva K.S. , Mordvinova E.D. , Yarovaya O.I. , Gatilov Y.V. , Shcherbakov D.N. , Bormotov N.I. , Serova O.A. , Shishkina L.N. , Salakhutdinov N.F.
Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles
Molecules. 2022. V.27. N15. 4761 :1-21. DOI: 10.3390/molecules27154761 WOS РИНЦ
Dates:
Submitted: Jun 27, 2022
Accepted: Jul 20, 2022
Published online: Jul 25, 2022
Identifiers:
Web of science WOS:000839681900001
Elibrary 58554985
OpenAlex W4287878177
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