Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles

Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles Научная публикация

Журнал

Molecules
, E-ISSN: 1420-3049

Вых. Данные

Год: 2022, Том: 27, Номер: 15, Номер статьи : 4761, Страниц : 21 DOI: 10.3390/molecules27154761

Ключевые слова

monoterpenoids; monoterpenes; vaccinia virus; Marburg virus; heterocyclic compounds

Авторы

Oreshko Vladislav V. ^1,2 , Kovaleva Kseniya S. ¹ , Mordvinova Ekaterina D. ^2,3 , Yarovaya Olga I. ^1,2 , Gatilov Yuri V. ¹ , Shcherbakov Dmitry N. ³ , Bormotov Nikolai I. ³ , Serova Olga A. ³ , Shishkina Larisa N. ³ , Salakhutdinov Nariman F. ¹

Организации

1	Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave. 9, 630090 Novosibirsk, Russia
2	Zelman Institute for Medicine and Psychology, Novosibirsk State University, Pirogova St., 1, 630090 Novosibirsk, Russia
3	State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia

A set of heterocyclic products was synthesized from natural (+)-camphor and semi-synthetic (−)-camphor. Then, 2-Imino-4-thiazolidinones and 2,3-dihydrothiazoles were obtained using a three-step procedure. For the synthesized compounds, their antiviral activity against the vaccinia virus and Marburg virus was studied. New promising agents active against both viruses were found among the tested compounds.

Oreshko V.V. , Kovaleva K.S. , Mordvinova E.D. , Yarovaya O.I. , Gatilov Y.V. , Shcherbakov D.N. , Bormotov N.I. , Serova O.A. , Shishkina L.N. , Salakhutdinov N.F.
Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles
Molecules. 2022. V.27. N15. 4761 :1-21. DOI: 10.3390/molecules27154761 WOS РИНЦ

Поступила в редакцию:	27 июн. 2022 г.
Принята к публикации:	20 июл. 2022 г.
Опубликована online:	25 июл. 2022 г.

Web of science	WOS:000839681900001
РИНЦ	58554985
OpenAlex	W4287878177