Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity

Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2023, Volume: 72, Number: 1, Pages: 248-262 Pages count : 15 DOI: 10.1007/s11172-023-3730-4

Tags

colchicine, monoterpenoids, SARS-Cov-2 3CLPro, molecular docking, antiproliferative activity

Authors

Shchegravina E.S. ¹ , Usova S.D. ¹ , Baev D.S. ² , Mozhaitsev E.S. ² , Shcherbakov D.N. ³ , Belenkaya S.V. ^3,4 , Volosnikova E.A. ³ , Chirkova V.Yu. ⁵ , Sharlaeva E.A. ⁵ , Svirshchevskaya E.V. ⁶ , Fonareva I.P. ¹ , Sitdikova A.R. ¹ , Salakhutdinov N.F. ² , Yarovaya O.I. ² , Fedorov A.Yu. ¹

Affiliations

1	Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation
2	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent´eva, 630090 Novosibirsk, Russian Federation
3	State Scientiﬁc Center of Virology and Biotechnology "Vector", 630559 Koltsovo, Novosibirsk Region, Russian Federation
4	Novosibirsk State University, 1 ul. Pirogova, 630090 Novosibirsk, Russian Federation
5	Altai State University, 61 Leninsky prosp., 656049 Barnaul, Russian Federation
6	Department of Immunology, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, 117997 Moscow, Russian Federation

Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.

Shchegravina E.S. , Usova S.D. , Baev D.S. , Mozhaitsev E.S. , Shcherbakov D.N. , Belenkaya S.V. , Volosnikova E.A. , Chirkova V.Y. , Sharlaeva E.A. , Svirshchevskaya E.V. , Fonareva I.P. , Sitdikova A.R. , Salakhutdinov N.F. , Yarovaya O.I. , Fedorov A.Y.
Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
Russian Chemical Bulletin. 2023. V.72. N1. P.248-262. DOI: 10.1007/s11172-023-3730-4 WOS Scopus РИНЦ

Щегравина Е.С. , Усова С.Д. , Баев Д.С. , Можайцев Е.С. , Щербаков Д.Н. , Беленькая С.В. , Волосникова Е.А. , Чиркова В.Ю. , Шарлаева Е.А. , Свирщевская Е.В. , Фонарева И.П. , Ситдикова А.Р. , Салахутдинов Н.Ф. , Яровая О.И. , Фёдоров А.Ю.
СИНТЕЗ КОНЪЮГАТОВ (AR,7S)-КОЛХИЦИНА С МОНОТЕРПЕНОИДАМИ И ИЗУЧЕНИЕ ИХ БИОЛОГИЧЕСКОЙ АКТИВНОСТИ
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2023. Т.72. №1. С.248-262. РИНЦ

Submitted:	Apr 28, 2022
Accepted:	May 25, 2022
Published print:	Feb 14, 2023

Web of science	WOS:000933481700020
Scopus	2-s2.0-85148438386
Elibrary	60810281
OpenAlex	W4320736160