Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity

Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Вых. Данные

Год: 2023, Том: 72, Номер: 1, Страницы: 248-262 Страниц : 15 DOI: 10.1007/s11172-023-3730-4

Ключевые слова

colchicine, monoterpenoids, SARS-Cov-2 3CLPro, molecular docking, antiproliferative activity

Авторы

Shchegravina E.S. ¹ , Usova S.D. ¹ , Baev D.S. ² , Mozhaitsev E.S. ² , Shcherbakov D.N. ³ , Belenkaya S.V. ^3,4 , Volosnikova E.A. ³ , Chirkova V.Yu. ⁵ , Sharlaeva E.A. ⁵ , Svirshchevskaya E.V. ⁶ , Fonareva I.P. ¹ , Sitdikova A.R. ¹ , Salakhutdinov N.F. ² , Yarovaya O.I. ² , Fedorov A.Yu. ¹

Организации

1	Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation
2	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent´eva, 630090 Novosibirsk, Russian Federation
3	State Scientiﬁc Center of Virology and Biotechnology "Vector", 630559 Koltsovo, Novosibirsk Region, Russian Federation
4	Novosibirsk State University, 1 ul. Pirogova, 630090 Novosibirsk, Russian Federation
5	Altai State University, 61 Leninsky prosp., 656049 Barnaul, Russian Federation
6	Department of Immunology, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, 117997 Moscow, Russian Federation

Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.

Shchegravina E.S. , Usova S.D. , Baev D.S. , Mozhaitsev E.S. , Shcherbakov D.N. , Belenkaya S.V. , Volosnikova E.A. , Chirkova V.Y. , Sharlaeva E.A. , Svirshchevskaya E.V. , Fonareva I.P. , Sitdikova A.R. , Salakhutdinov N.F. , Yarovaya O.I. , Fedorov A.Y.
Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
Russian Chemical Bulletin. 2023. V.72. N1. P.248-262. DOI: 10.1007/s11172-023-3730-4 WOS Scopus РИНЦ

Щегравина Е.С. , Усова С.Д. , Баев Д.С. , Можайцев Е.С. , Щербаков Д.Н. , Беленькая С.В. , Волосникова Е.А. , Чиркова В.Ю. , Шарлаева Е.А. , Свирщевская Е.В. , Фонарева И.П. , Ситдикова А.Р. , Салахутдинов Н.Ф. , Яровая О.И. , Фёдоров А.Ю.
СИНТЕЗ КОНЪЮГАТОВ (AR,7S)-КОЛХИЦИНА С МОНОТЕРПЕНОИДАМИ И ИЗУЧЕНИЕ ИХ БИОЛОГИЧЕСКОЙ АКТИВНОСТИ
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2023. Т.72. №1. С.248-262. РИНЦ

Поступила в редакцию:	28 апр. 2022 г.
Принята к публикации:	25 мая 2022 г.
Опубликована в печати:	14 февр. 2023 г.

Web of science	WOS:000933481700020
Scopus	2-s2.0-85148438386
РИНЦ	60810281
OpenAlex	W4320736160