Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene

Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene Full article

Journal

Mendeleev Communications
ISSN: 0959-9436

Output data

Year: 2022, Volume: 32, Number: 5, Pages: 609-611 Pages count : 3 DOI: 10.1016/j.mencom.2022.09.013

Authors

Yarovaya Olga I. ¹ , Kovaleva Kseniya S. ¹ , Borisevich Sophia S. ² , Rybalova Tatyana V. ¹ , Gatilov Yuriy V. ¹ , Sinegubova Ekaterina O. ³ , Volobueva Alexandrina S. ³ , Zarubaev Vladimir V. ³ , Salakhutdinov Nariman F. ¹

Affiliations

1	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
2	Ufa Institute of Chemistry, RAS
3	Saint Petersburg Pasteur Institute

The Ritter reaction of humulene with acetonitrile occurs as the biomimetic process to afford the amide having the skeleton of a natural alcohol. The structures of the amides obtained from humulene and caryophyllene were confirmed by XRD data. The activity of some cage compounds against influenza virus allowed one to suggest the mechanism of antiviral action based on interfering with membrane fusion activity of viral hemagglutinin.

Yarovaya O.I. , Kovaleva K.S. , Borisevich S.S. , Rybalova T.V. , Gatilov Y.V. , Sinegubova E.O. , Volobueva A.S. , Zarubaev V.V. , Salakhutdinov N.F.
Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene
Mendeleev Communications. 2022. V.32. N5. P.609-611. DOI: 10.1016/j.mencom.2022.09.013 WOS РИНЦ

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