Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene

Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene Научная публикация

Журнал

Mendeleev Communications
ISSN: 0959-9436

Вых. Данные

Год: 2022, Том: 32, Номер: 5, Страницы: 609-611 Страниц : 3 DOI: 10.1016/j.mencom.2022.09.013

Авторы

Yarovaya Olga I. ¹ , Kovaleva Kseniya S. ¹ , Borisevich Sophia S. ² , Rybalova Tatyana V. ¹ , Gatilov Yuriy V. ¹ , Sinegubova Ekaterina O. ³ , Volobueva Alexandrina S. ³ , Zarubaev Vladimir V. ³ , Salakhutdinov Nariman F. ¹

Организации

1	Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАН
2	Уфимский Институт химии Российской академии наук
3	Федеральное бюджетное учреждение науки Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. Пастера

The Ritter reaction of humulene with acetonitrile occurs as the biomimetic process to afford the amide having the skeleton of a natural alcohol. The structures of the amides obtained from humulene and caryophyllene were confirmed by XRD data. The activity of some cage compounds against influenza virus allowed one to suggest the mechanism of antiviral action based on interfering with membrane fusion activity of viral hemagglutinin.

Yarovaya O.I. , Kovaleva K.S. , Borisevich S.S. , Rybalova T.V. , Gatilov Y.V. , Sinegubova E.O. , Volobueva A.S. , Zarubaev V.V. , Salakhutdinov N.F.
Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene
Mendeleev Communications. 2022. V.32. N5. P.609-611. DOI: 10.1016/j.mencom.2022.09.013 WOS РИНЦ

Web of science	WOS:000874166100013
РИНЦ	53959982
OpenAlex	W4302759495