Sciact
  • EN
  • RU

Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives Full article

Journal International Journal of Molecular Sciences
ISSN: 1661-6596
Output data Year: 2022, Volume: 23, Number: 22, Pages: 14186 Pages count : 1 DOI: 10.3390/ijms232214186
Tags berberine derivatives; metabolic syndrome; hypoglycemic activity; OGTT; agouti yellow mice
Authors Khvostov Mikhail V. 1 , Gladkova Elizaveta D. 1,2 , Borisov Sergey A. 1 , Fedotova Marina S. 1,2 , Zhukova Nataliya A. 1 , Marenina Mariya K. 1 , Meshkova Yuliya V. 1 , Luzina Olga A. 1 , Tolstikova Tatiana G. 1 , Salakhutdinov Nariman F. 1
Affiliations
1 N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
2 Novosibirsk State University

Abstract: Novel 9-N-alkyltetrahydroberberine derivatives were synthesized, among which, based on the results of OGTT, one compound containing the longest aliphatic substituent was selected for study in mice C57BL/6Ay, which demonstrate obesity, impaired glucose tolerance, and concomitant liver non-alcoholic fatty disease. Administration of this substance at a dose of 15 mg/kg for four weeks improved the insulin sensitivity of mice, which resulted in a decrease in fasting glucose levels and improved the tolerance of mice to OGTT glucose loading. A decrease in the level of lactate in the blood and a decrease in the amount of glucokinase in the liver were also found. The introduction of compound 3c did not have a toxic effect on animals based on biochemical data, histological analysis, and measurements of general parameters such as body weight and feed intake. Thus, the 9-N-heptyltetrahydroberberine derivative showed prominent hypoglycemic effects, which makes it promising to obtain and study other derivatives with longer substituents.
Cite: Khvostov M.V. , Gladkova E.D. , Borisov S.A. , Fedotova M.S. , Zhukova N.A. , Marenina M.K. , Meshkova Y.V. , Luzina O.A. , Tolstikova T.G. , Salakhutdinov N.F.
Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives
International Journal of Molecular Sciences. 2022. V.23. N22. P.14186. DOI: 10.3390/ijms232214186 WOS РИНЦ
Dates:
Submitted: Oct 25, 2022
Accepted: Nov 14, 2022
Published online: Nov 16, 2022
Identifiers:
Web of science WOS:000887316400001
Elibrary 57677005
OpenAlex W4309687190
Altmetrics: