Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives

Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives Научная публикация

Журнал

International Journal of Molecular Sciences
ISSN: 1661-6596

Вых. Данные

Год: 2022, Том: 23, Номер: 22, Страницы: 14186 Страниц : 1 DOI: 10.3390/ijms232214186

Ключевые слова

berberine derivatives; metabolic syndrome; hypoglycemic activity; OGTT; agouti yellow mice

Авторы

Khvostov Mikhail V. ¹ , Gladkova Elizaveta D. ^1,2 , Borisov Sergey A. ¹ , Fedotova Marina S. ^1,2 , Zhukova Nataliya A. ¹ , Marenina Mariya K. ¹ , Meshkova Yuliya V. ¹ , Luzina Olga A. ¹ , Tolstikova Tatiana G. ¹ , Salakhutdinov Nariman F. ¹

Организации

1	Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАН
2	Новосибирский национальный исследовательский государственный университет

Novel 9-N-alkyltetrahydroberberine derivatives were synthesized, among which, based on the results of OGTT, one compound containing the longest aliphatic substituent was selected for study in mice C57BL/6Ay, which demonstrate obesity, impaired glucose tolerance, and concomitant liver non-alcoholic fatty disease. Administration of this substance at a dose of 15 mg/kg for four weeks improved the insulin sensitivity of mice, which resulted in a decrease in fasting glucose levels and improved the tolerance of mice to OGTT glucose loading. A decrease in the level of lactate in the blood and a decrease in the amount of glucokinase in the liver were also found. The introduction of compound 3c did not have a toxic effect on animals based on biochemical data, histological analysis, and measurements of general parameters such as body weight and feed intake. Thus, the 9-N-heptyltetrahydroberberine derivative showed prominent hypoglycemic effects, which makes it promising to obtain and study other derivatives with longer substituents.

Khvostov M.V. , Gladkova E.D. , Borisov S.A. , Fedotova M.S. , Zhukova N.A. , Marenina M.K. , Meshkova Y.V. , Luzina O.A. , Tolstikova T.G. , Salakhutdinov N.F.
Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives
International Journal of Molecular Sciences. 2022. V.23. N22. P.14186. DOI: 10.3390/ijms232214186 WOS РИНЦ

Поступила в редакцию:	25 окт. 2022 г.
Принята к публикации:	14 нояб. 2022 г.
Опубликована online:	16 нояб. 2022 г.

Web of science	WOS:000887316400001
РИНЦ	57677005
OpenAlex	W4309687190