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Gel chromatographic and toxicological studies of the mechanochemical transformations of water-soluble polysaccharides Full article

Journal Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031
Output data Year: 2013, Volume: 46, Number: 10, Pages: 630-633 Pages count : DOI: 10.1007/s11094-013-0859-8
Tags polysaccharides; mechanochemistry; molecular weight distribution; gel chromatography; toxicity
Authors Dushkin A. V. 1 , Meteleva E. S. 1 , Tolstikova T. G. 2 , Pavlova A. V. 2 , Khvostov M. V. 2
Affiliations
1 (Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Solid State Chem & Mechanochem ISSCM, Novosibirsk, Russia
2 (Данные Web of science) Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Branch, Novosibirsk, Russia

Abstract: Changes in the molecular weight characteristics of polysaccharide macromolecules - arabinogalactan, hydroxyethyl starch 200/0.5, Fibregum, and dextrans 10, 40, and 70 - were studied during mechanochemical processing. A preference for "gentle" conditions for mechanical processing (similar to 1 g) were established, as these conditions do not lead to destruction of polysaccharide macromolecules. An additional advantage of these mechanical processing regimes is that they can be scaled up to industrial flow mills. Mechanochemical processing had no adverse effect on the toxicity measures of the polysaccharides studied. Toxicological studies of mechanically processed arabinogalactan, hydroxyethyl starch 200/0.5, Fibregum, and dextrans 10, 40, and 70 showed that these polysaccharides and the products of their mechanochemical processing can be classified as class 4 (low-toxicity) substances.
Cite: Dushkin A.V. , Meteleva E.S. , Tolstikova T.G. , Pavlova A.V. , Khvostov M.V.
Gel chromatographic and toxicological studies of the mechanochemical transformations of water-soluble polysaccharides
Pharmaceutical Chemistry Journal. 2013. V.46. N10. P.630-633. DOI: 10.1007/s11094-013-0859-8 WOS Scopus РИНЦ
ArticleLinkType.TRANSLATED_TO_ORIGINAL: Душкин А.В. , Метелева Е.С. , Толстикова Т.Г. , Павлова А.В. , Хвостов М.В.
ГЕЛЬ-ХРОМАТОГРАФИЧЕСКОЕ И ТОКСИКОЛОГИЧЕСКОЕ ИССЛЕДОВАНИЕ МЕХАНОХИМИЧЕСКИХ ПРЕВРАЩЕНИЙ ВОДОРАСТВОРИМЫХ ПОЛИСАХАРИДОВ
Химико-фармацевтический журнал (PHARM CHEM J+). 2012. Т.46. №10. С.53-56. РИНЦ
Dates:
Published print: Jan 1, 2013
Published online: Feb 23, 2013
Identifiers:
Web of science WOS:000315443200010
Scopus 2-s2.0-84874657709
Elibrary 20432181
OpenAlex W2167074560
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