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Gel chromatographic and toxicological studies of the mechanochemical transformations of water-soluble polysaccharides Научная публикация

Журнал Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031
Вых. Данные Год: 2013, Том: 46, Номер: 10, Страницы: 630-633 Страниц : DOI: 10.1007/s11094-013-0859-8
Ключевые слова polysaccharides; mechanochemistry; molecular weight distribution; gel chromatography; toxicity
Авторы Dushkin A. V. 1 , Meteleva E. S. 1 , Tolstikova T. G. 2 , Pavlova A. V. 2 , Khvostov M. V. 2
Организации
1 (Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Solid State Chem & Mechanochem ISSCM, Novosibirsk, Russia
2 (Данные Web of science) Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Branch, Novosibirsk, Russia

Реферат: Changes in the molecular weight characteristics of polysaccharide macromolecules - arabinogalactan, hydroxyethyl starch 200/0.5, Fibregum, and dextrans 10, 40, and 70 - were studied during mechanochemical processing. A preference for "gentle" conditions for mechanical processing (similar to 1 g) were established, as these conditions do not lead to destruction of polysaccharide macromolecules. An additional advantage of these mechanical processing regimes is that they can be scaled up to industrial flow mills. Mechanochemical processing had no adverse effect on the toxicity measures of the polysaccharides studied. Toxicological studies of mechanically processed arabinogalactan, hydroxyethyl starch 200/0.5, Fibregum, and dextrans 10, 40, and 70 showed that these polysaccharides and the products of their mechanochemical processing can be classified as class 4 (low-toxicity) substances.
Библиографическая ссылка: Dushkin A.V. , Meteleva E.S. , Tolstikova T.G. , Pavlova A.V. , Khvostov M.V.
Gel chromatographic and toxicological studies of the mechanochemical transformations of water-soluble polysaccharides
Pharmaceutical Chemistry Journal. 2013. V.46. N10. P.630-633. DOI: 10.1007/s11094-013-0859-8 WOS Scopus РИНЦ
Оригинальная версия: Душкин А.В. , Метелева Е.С. , Толстикова Т.Г. , Павлова А.В. , Хвостов М.В.
ГЕЛЬ-ХРОМАТОГРАФИЧЕСКОЕ И ТОКСИКОЛОГИЧЕСКОЕ ИССЛЕДОВАНИЕ МЕХАНОХИМИЧЕСКИХ ПРЕВРАЩЕНИЙ ВОДОРАСТВОРИМЫХ ПОЛИСАХАРИДОВ
Химико-фармацевтический журнал (PHARM CHEM J+). 2012. Т.46. №10. С.53-56. РИНЦ
Даты:
Опубликована в печати: 1 янв. 2013 г.
Опубликована online: 23 февр. 2013 г.
Идентификаторы:
Web of science WOS:000315443200010
Scopus 2-s2.0-84874657709
РИНЦ 20432181
OpenAlex W2167074560
Альметрики: