Synthetic transformations of higher triterpenoids. XXX. Synthesis and cytotoxic activity of betulonic acid amides with fragments of nitroxyl radicals Full article
| Journal |
Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620 |
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| Output data | Year: 2013, Volume: 39, Number: 2, Pages: 181-185 Pages count : 5 DOI: 10.1134/S1068162013020027 | ||||
| Tags | betulin; betulonic acid; amides; nitroxyl radicals; tumor cells | ||||
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Abstract:
Interaction of betulonic acid chloride with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, 3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl, and 3-aminomethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl yielded the corresponding triterpene amides. The synthesized derivatives of betulonic acid were shown to exhibit a cytotoxic activity on models of the CEM-13, U-937, and MT-4 tumor cells. The concentration of the most active N-[3-oxo-28-norlup-20(29)-en-17-carbamoyl-(2,2,6,6-tetramethylpiperidine-4-yl)-1-oxyl that inhibited survival of the tumor cells by 50% (CCID50) proved to be 5.7-33.1 mu M.
Cite:
Antimonova A.N.
, Petrenko N.I.
, Shults E.E.
, Polienko Y.F.
, Shakirov M.M.
, Irtegova I.G.
, Pokrovskii M.A.
, Sherman K.M.
, Grigor'ev I.A.
, Pokrovskii A.G.
, Tolstikov G.A.
Synthetic transformations of higher triterpenoids. XXX. Synthesis and cytotoxic activity of betulonic acid amides with fragments of nitroxyl radicals
Russian Journal of Bioorganic Chemistry. 2013. V.39. N2. P.181-185. DOI: 10.1134/S1068162013020027 WOS Scopus РИНЦ
Synthetic transformations of higher triterpenoids. XXX. Synthesis and cytotoxic activity of betulonic acid amides with fragments of nitroxyl radicals
Russian Journal of Bioorganic Chemistry. 2013. V.39. N2. P.181-185. DOI: 10.1134/S1068162013020027 WOS Scopus РИНЦ
Dates:
| Published print: | Mar 1, 2013 |
| Published online: | Mar 22, 2013 |
Identifiers:
| Web of science | WOS:000316686600009 |
| Scopus | 2-s2.0-84880754745 |
| Elibrary | 20446746 |
| OpenAlex | W1986863633 |