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Synthetic transformations of higher triterpenoids. XXX. Synthesis and cytotoxic activity of betulonic acid amides with fragments of nitroxyl radicals Научная публикация

Журнал Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620
Вых. Данные Год: 2013, Том: 39, Номер: 2, Страницы: 181-185 Страниц : 5 DOI: 10.1134/S1068162013020027
Ключевые слова betulin; betulonic acid; amides; nitroxyl radicals; tumor cells
Авторы Antimonova A.N. 1 , Petrenko N.I. 1 , Shults E.E. 1 , Polienko Yu F. 1 , Shakirov M.M. 1 , Irtegova I.G. 1 , Pokrovskii M.A. 2 , Sherman K.M. 2 , Grigor'ev I.A. 1 , Pokrovskii A.G. 2 , Tolstikov G.A. 1
Организации
1 (Данные Web of science) Russian Acad Sci, Vorozhtsov Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

Реферат: Interaction of betulonic acid chloride with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, 3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl, and 3-aminomethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl yielded the corresponding triterpene amides. The synthesized derivatives of betulonic acid were shown to exhibit a cytotoxic activity on models of the CEM-13, U-937, and MT-4 tumor cells. The concentration of the most active N-[3-oxo-28-norlup-20(29)-en-17-carbamoyl-(2,2,6,6-tetramethylpiperidine-4-yl)-1-oxyl that inhibited survival of the tumor cells by 50% (CCID50) proved to be 5.7-33.1 mu M.
Библиографическая ссылка: Antimonova A.N. , Petrenko N.I. , Shults E.E. , Polienko Y.F. , Shakirov M.M. , Irtegova I.G. , Pokrovskii M.A. , Sherman K.M. , Grigor'ev I.A. , Pokrovskii A.G. , Tolstikov G.A.
Synthetic transformations of higher triterpenoids. XXX. Synthesis and cytotoxic activity of betulonic acid amides with fragments of nitroxyl radicals
Russian Journal of Bioorganic Chemistry. 2013. V.39. N2. P.181-185. DOI: 10.1134/S1068162013020027 WOS Scopus РИНЦ
Даты:
Опубликована в печати: 1 мар. 2013 г.
Опубликована online: 22 мар. 2013 г.
Идентификаторы:
Web of science WOS:000316686600009
Scopus 2-s2.0-84880754745
РИНЦ 20446746
OpenAlex W1986863633
Альметрики: