Synthesis of aminopropylamino derivatives of betulinic and oleanolic acids

Synthesis of aminopropylamino derivatives of betulinic and oleanolic acids Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Output data

Year: 2013, Volume: 39, Number: 3, Pages: 329-337 Pages count : DOI: 10.1134/S1068162013020064

Tags

triterpenoids; amides; cyanoethylation; aminopropylamino derivatives; anti-inflammatory activity

Authors

Giniyatullina G. V. ¹ , Kazakova O. B. ¹ , Medvedeva N. I. ¹ , Sorokina I. V. ² , Zhukova N. A. ² , Tolstikova T. G. ² , Tolstikov G. A. ²

Affiliations

1	(Данные Web of science) Russian Acad Sci, Inst Organ Chem, Ufa Res Ctr, Ufa 45054, Russia
2	(Данные Web of science) Russian Acad Sci, Vorozhtsov Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

Triterpenoids with the following amine fragments in C3 and C28 positions were synthesized on the basis of betulinic and oleanolic acids: (3-aminopropoxy)-, 3-acetyl-(3-aminopropyl)amino-, 6-[bis(3-aminopropyl)amino]hexylamino-, and (3-aminopropyl)-4-aminophenylsulfonyl-4-phenylamino. Amide of betulonic acid with 4,4'-diaminodiphenylsulfonic substituent was shown to exhibit no antitumor effect, but to have a pronounced anti-inflammatory activity.

Giniyatullina G.V. , Kazakova O.B. , Medvedeva N.I. , Sorokina I.V. , Zhukova N.A. , Tolstikova T.G. , Tolstikov G.A.
Synthesis of aminopropylamino derivatives of betulinic and oleanolic acids
Russian Journal of Bioorganic Chemistry. 2013. V.39. N3. P.329-337. DOI: 10.1134/S1068162013020064 WOS Scopus РИНЦ

Published print:	May 1, 2013
Published online:	May 24, 2013

Web of science	WOS:000319358100012
Scopus	2-s2.0-84878734765
Elibrary	20440040
OpenAlex	W1980694662