Synthesis of aminopropylamino derivatives of betulinic and oleanolic acids

Synthesis of aminopropylamino derivatives of betulinic and oleanolic acids Научная публикация

Журнал

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Вых. Данные

Год: 2013, Том: 39, Номер: 3, Страницы: 329-337 Страниц : DOI: 10.1134/S1068162013020064

Ключевые слова

triterpenoids; amides; cyanoethylation; aminopropylamino derivatives; anti-inflammatory activity

Авторы

Giniyatullina G. V. ¹ , Kazakova O. B. ¹ , Medvedeva N. I. ¹ , Sorokina I. V. ² , Zhukova N. A. ² , Tolstikova T. G. ² , Tolstikov G. A. ²

Организации

1	(Данные Web of science) Russian Acad Sci, Inst Organ Chem, Ufa Res Ctr, Ufa 45054, Russia
2	(Данные Web of science) Russian Acad Sci, Vorozhtsov Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

Triterpenoids with the following amine fragments in C3 and C28 positions were synthesized on the basis of betulinic and oleanolic acids: (3-aminopropoxy)-, 3-acetyl-(3-aminopropyl)amino-, 6-[bis(3-aminopropyl)amino]hexylamino-, and (3-aminopropyl)-4-aminophenylsulfonyl-4-phenylamino. Amide of betulonic acid with 4,4'-diaminodiphenylsulfonic substituent was shown to exhibit no antitumor effect, but to have a pronounced anti-inflammatory activity.

Giniyatullina G.V. , Kazakova O.B. , Medvedeva N.I. , Sorokina I.V. , Zhukova N.A. , Tolstikova T.G. , Tolstikov G.A.
Synthesis of aminopropylamino derivatives of betulinic and oleanolic acids
Russian Journal of Bioorganic Chemistry. 2013. V.39. N3. P.329-337. DOI: 10.1134/S1068162013020064 WOS Scopus РИНЦ

Опубликована в печати:	1 мая 2013 г.
Опубликована online:	24 мая 2013 г.

Web of science	WOS:000319358100012
Scopus	2-s2.0-84878734765
РИНЦ	20440040
OpenAlex	W1980694662