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Alteration of Warfarin's Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan Full article

Journal Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X
Output data Year: 2011, Volume: 8, Number: 3, Pages: 201-204 Pages count : 4 DOI: 10.2174/157018011794578222
Tags Arabinogalactan; Clathration; Glycyrrhizic acid; Warfarin
Authors Tolstikov Tatjana G. 1 , Khvostov Mikhail V. 1 , Lifshits Galina I. 2 , Dushkin Alexander V. 3 , Meteleva Elezaveta S. 3
Affiliations
1 N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 9 Acad. Lavrentjev Ave., Novosibirsk, 630090, Russian Federation
2 Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 8 Acad. Lavrentjev Ave., Novosibirsk, 630090, Russian Federation
3 Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 8 Acad. Lavrentjev Ave., Novosibirsk, 630090, Russian Federation

Abstract: The article describes the pharmacological examinations of clathrates of warfarin (WF) with glycyrrhizic acid (GA) and arabinogalactan (AG). A direct connection between the clathrate structure and the pharmacon's anticoagulative properties was observed. A 20 mg/kg (WF 2 mg/kg) dose of WF: GA 1:10 clathrate causes the increase in prothrombin time (PT) only in 54 hours, after 3 administrations. In contrast, a 20 mg/kg (WF 2 mg/kg) dose of WF: AG 1:10 clathrate leads to an increase in PT in 24 and 48 hours after a single administration, which corresponds to the effect of a comparator agent WF (2 mg/kg).
Cite: Tolstikov T.G. , Khvostov M.V. , Lifshits G.I. , Dushkin A.V. , Meteleva E.S.
Alteration of Warfarin's Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan
Letters in Drug Design and Discovery. 2011. V.8. N3. P.201-204. DOI: 10.2174/157018011794578222 WOS Scopus РИНЦ
Dates:
Published print: Mar 1, 2011
Identifiers:
Web of science WOS:000288983500001
Scopus 2-s2.0-79952292772
Elibrary 16664257
OpenAlex W2334599523
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