Alteration of Warfarin's Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan

Alteration of Warfarin's Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan Научная публикация

Журнал

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Вых. Данные

Год: 2011, Том: 8, Номер: 3, Страницы: 201-204 Страниц : 4 DOI: 10.2174/157018011794578222

Ключевые слова

Arabinogalactan; Clathration; Glycyrrhizic acid; Warfarin

Авторы

Tolstikov Tatjana G. ¹ , Khvostov Mikhail V. ¹ , Lifshits Galina I. ² , Dushkin Alexander V. ³ , Meteleva Elezaveta S. ³

Организации

1	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 9 Acad. Lavrentjev Ave., Novosibirsk, 630090, Russian Federation
2	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 8 Acad. Lavrentjev Ave., Novosibirsk, 630090, Russian Federation
3	Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 8 Acad. Lavrentjev Ave., Novosibirsk, 630090, Russian Federation

The article describes the pharmacological examinations of clathrates of warfarin (WF) with glycyrrhizic acid (GA) and arabinogalactan (AG). A direct connection between the clathrate structure and the pharmacon's anticoagulative properties was observed. A 20 mg/kg (WF 2 mg/kg) dose of WF: GA 1:10 clathrate causes the increase in prothrombin time (PT) only in 54 hours, after 3 administrations. In contrast, a 20 mg/kg (WF 2 mg/kg) dose of WF: AG 1:10 clathrate leads to an increase in PT in 24 and 48 hours after a single administration, which corresponds to the effect of a comparator agent WF (2 mg/kg).

Tolstikov T.G. , Khvostov M.V. , Lifshits G.I. , Dushkin A.V. , Meteleva E.S.
Alteration of Warfarin's Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan
Letters in Drug Design and Discovery. 2011. V.8. N3. P.201-204. DOI: 10.2174/157018011794578222 WOS Scopus РИНЦ

Опубликована в печати:

1 мар. 2011 г.

Web of science	WOS:000288983500001
Scopus	2-s2.0-79952292772
РИНЦ	16664257
OpenAlex	W2334599523