Glycidipine, a Promising Hypotensive and Cardioprotective Agent

Glycidipine, a Promising Hypotensive and Cardioprotective Agent Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2011, Volume: 151, Number: 5, Pages: 597-600 Pages count : 4 DOI: 10.1007/s10517-011-1391-z

Tags

vegetable metabolites; complexes; hypotensive and cardioprotective activity; rats

Authors

Tolstikova T.G. ¹ , Khvostov M.V. ¹ , Bryzgalov A.O. ¹ , Belenichev I.F. ² , Pavlov S.V. ²

Affiliations

1	N. N. Vorozhtsov Institute of the Organic Chemistry, Russian Academy of Sciences, Novosibirsk, Russian Federation
2	Zaporozhye State Medical University, Ukraine State Medical University, Zaporizhia, Ukraine

Toxicological pharmacological study of the molecular complex of nifedipine and glycyrrhizic acid 1:10 (glycidipine) obtained using mechanochemical technique was carried out. High hypotensive and cardioprotective effects of the agent were demonstrated. Chronic administration (45 days) produced no toxic effects in vital organs and systems of Wistar rats and ISIAH rats.

Tolstikova T.G. , Khvostov M.V. , Bryzgalov A.O. , Belenichev I.F. , Pavlov S.V.
Glycidipine, a Promising Hypotensive and Cardioprotective Agent
Bulletin of Experimental Biology and Medicine. 2011. V.151. N5. P.597-600. DOI: 10.1007/s10517-011-1391-z WOS Scopus РИНЦ

Published print:	Sep 1, 2011
Published online:	Sep 22, 2011

Web of science	WOS:000295414800012
Scopus	2-s2.0-80054682342
Elibrary	18009537
OpenAlex	W1968677522