Glycidipine, a Promising Hypotensive and Cardioprotective Agent

Glycidipine, a Promising Hypotensive and Cardioprotective Agent Научная публикация

Журнал

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Вых. Данные

Год: 2011, Том: 151, Номер: 5, Страницы: 597-600 Страниц : 4 DOI: 10.1007/s10517-011-1391-z

Ключевые слова

vegetable metabolites; complexes; hypotensive and cardioprotective activity; rats

Авторы

Tolstikova T.G. ¹ , Khvostov M.V. ¹ , Bryzgalov A.O. ¹ , Belenichev I.F. ² , Pavlov S.V. ²

Организации

1	N. N. Vorozhtsov Institute of the Organic Chemistry, Russian Academy of Sciences, Novosibirsk, Russian Federation
2	Zaporozhye State Medical University, Ukraine State Medical University, Zaporizhia, Ukraine

Toxicological pharmacological study of the molecular complex of nifedipine and glycyrrhizic acid 1:10 (glycidipine) obtained using mechanochemical technique was carried out. High hypotensive and cardioprotective effects of the agent were demonstrated. Chronic administration (45 days) produced no toxic effects in vital organs and systems of Wistar rats and ISIAH rats.

Tolstikova T.G. , Khvostov M.V. , Bryzgalov A.O. , Belenichev I.F. , Pavlov S.V.
Glycidipine, a Promising Hypotensive and Cardioprotective Agent
Bulletin of Experimental Biology and Medicine. 2011. V.151. N5. P.597-600. DOI: 10.1007/s10517-011-1391-z WOS Scopus РИНЦ

Опубликована в печати:	1 сент. 2011 г.
Опубликована online:	22 сент. 2011 г.

Web of science	WOS:000295414800012
Scopus	2-s2.0-80054682342
РИНЦ	18009537
OpenAlex	W1968677522