Complex of Nifedipine with Glycyrrhizic Acid as a Novel Water-Soluble Antihypertensive and Antiarrhythmic Agent

Complex of Nifedipine with Glycyrrhizic Acid as a Novel Water-Soluble Antihypertensive and Antiarrhythmic Agent Full article

Journal

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Output data

Year: 2009, Volume: 6, Number: 2, Pages: 155-158 Pages count : DOI: 10.2174/157018009787582688

Tags

Nifedipine; Glycyrrhizic acid; Drug delivery; Complexation

Authors

Tolstikova T. G. ¹ , Khvostov M. V. ¹ , Bryzgalov A. O. ¹ , Dushkin A. V. ² , Meteleva E. S. ²

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Solid State Chem & Mechanochem, Novosibirsk 630090, Russia

Present study describes the synthesis and pharmacological characteristics of the 18 glycyrrhizic acid complex with nifedipine, molecular composition 1:4. The study showed that complex decreases arterial pressure at the dose of nifedipine 10 times smaller than the therapeutic dose. Antiarrhythmic effect of nifedipine in this complex was obtained at the dosage 29 times lower than that ensuring antihypertensive action.

Tolstikova T.G. , Khvostov M.V. , Bryzgalov A.O. , Dushkin A.V. , Meteleva E.S.
Complex of Nifedipine with Glycyrrhizic Acid as a Novel Water-Soluble Antihypertensive and Antiarrhythmic Agent
Letters in Drug Design and Discovery. 2009. V.6. N2. P.155-158. DOI: 10.2174/157018009787582688 WOS Scopus РИНЦ

Published print:

Mar 1, 2009

Web of science	WOS:000263970800011
Scopus	2-s2.0-61949390314
Elibrary	13607046
OpenAlex	W2047246057