Complex of Nifedipine with Glycyrrhizic Acid as a Novel Water-Soluble Antihypertensive and Antiarrhythmic Agent

Complex of Nifedipine with Glycyrrhizic Acid as a Novel Water-Soluble Antihypertensive and Antiarrhythmic Agent Научная публикация

Журнал

Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X

Вых. Данные

Год: 2009, Том: 6, Номер: 2, Страницы: 155-158 Страниц : DOI: 10.2174/157018009787582688

Ключевые слова

Nifedipine; Glycyrrhizic acid; Drug delivery; Complexation

Авторы

Tolstikova T. G. ¹ , Khvostov M. V. ¹ , Bryzgalov A. O. ¹ , Dushkin A. V. ² , Meteleva E. S. ²

Организации

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Solid State Chem & Mechanochem, Novosibirsk 630090, Russia

Present study describes the synthesis and pharmacological characteristics of the 18 glycyrrhizic acid complex with nifedipine, molecular composition 1:4. The study showed that complex decreases arterial pressure at the dose of nifedipine 10 times smaller than the therapeutic dose. Antiarrhythmic effect of nifedipine in this complex was obtained at the dosage 29 times lower than that ensuring antihypertensive action.

Tolstikova T.G. , Khvostov M.V. , Bryzgalov A.O. , Dushkin A.V. , Meteleva E.S.
Complex of Nifedipine with Glycyrrhizic Acid as a Novel Water-Soluble Antihypertensive and Antiarrhythmic Agent
Letters in Drug Design and Discovery. 2009. V.6. N2. P.155-158. DOI: 10.2174/157018009787582688 WOS Scopus РИНЦ

Опубликована в печати:

1 мар. 2009 г.

Web of science	WOS:000263970800011
Scopus	2-s2.0-61949390314
РИНЦ	13607046
OpenAlex	W2047246057