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Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma Full article

Journal Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888
Output data Year: 2006, Volume: 142, Number: 1, Pages: 69-72 Pages count : 4 DOI: 10.1007/s10517-006-0294-x
Tags transplantable tumor; antitumor effect; antimetastatic effect; betulonic acid; 2-and 3-[3-oxo-20(29)-lupen-28-oilamino]-propionic acid
Authors Sorokina I.V. 1 , Tolstikova T.G. 1 , Zhukova N.A. 1 , Petrenko N.I. 1 , Uzenkova N.V. 1 , Shul'ts E.E. 1 , Popova N.A. 2
Affiliations
1 Laboratory of Pharmacological Studies, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Russia
2 Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

Abstract: We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-alpha-alanine, beta-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.
Cite: Sorokina I.V. , Tolstikova T.G. , Zhukova N.A. , Petrenko N.I. , Uzenkova N.V. , Shul'ts E.E. , Popova N.A.
Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma
Bulletin of Experimental Biology and Medicine. 2006. V.142. N1. P.69-72. DOI: 10.1007/s10517-006-0294-x WOS Scopus РИНЦ
Dates:
Published print: Jul 1, 2006
Identifiers:
Web of science WOS:000242633100020
Scopus 2-s2.0-33750470388
Elibrary 13506978
OpenAlex W1987527513
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