Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma Научная публикация
| Журнал |
Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 |
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| Вых. Данные | Год: 2006, Том: 142, Номер: 1, Страницы: 69-72 Страниц : 4 DOI: 10.1007/s10517-006-0294-x | ||||
| Ключевые слова | transplantable tumor; antitumor effect; antimetastatic effect; betulonic acid; 2-and 3-[3-oxo-20(29)-lupen-28-oilamino]-propionic acid | ||||
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Реферат:
We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-alpha-alanine, beta-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.
Библиографическая ссылка:
Sorokina I.V.
, Tolstikova T.G.
, Zhukova N.A.
, Petrenko N.I.
, Uzenkova N.V.
, Shul'ts E.E.
, Popova N.A.
Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma
Bulletin of Experimental Biology and Medicine. 2006. V.142. N1. P.69-72. DOI: 10.1007/s10517-006-0294-x WOS Scopus РИНЦ
Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma
Bulletin of Experimental Biology and Medicine. 2006. V.142. N1. P.69-72. DOI: 10.1007/s10517-006-0294-x WOS Scopus РИНЦ
Даты:
| Опубликована в печати: | 1 июл. 2006 г. |
Идентификаторы:
| Web of science | WOS:000242633100020 |
| Scopus | 2-s2.0-33750470388 |
| РИНЦ | 13506978 |
| OpenAlex | W1987527513 |