A combinatorially convenient version of synthesis of 5-substituted oxazole-4-carboxylic acid ethyl esters

A combinatorially convenient version of synthesis of 5-substituted oxazole-4-carboxylic acid ethyl esters Full article

Journal

Russian Journal of Organic Chemistry
ISSN: 1070-4280 , E-ISSN: 1608-3393

Output data

Year: 2006, Volume: 42, Number: 7, Pages: 1031-1035 Pages count : 5 DOI: 10.1134/S1070428006070177

Authors

Tormyshev V.M. ¹ , Mikhalina T.V. ¹ , Rogozhnikova O.Yu. ¹ , Troitskaya T.I. ¹ , Trukhin D.V. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Div, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

Reaction of ethyl isocyanoacetic acid with sodium hydride in anhydrous benzene, followed by treatment with carboxylic acid chlorides or N-(acyloxy)pyrrolidine-2,5-diones, gives 5-substituted oxazole-4-carboxylic acid esters. The procedure is applicable to derivatives of various carboxylic acids, including saturated aliphatic, alpha,beta-unsaturated, alicyclic, aromatic, heterocyclic, and N-Boc-protected amino acids.

Tormyshev V.M. , Mikhalina T.V. , Rogozhnikova O.Y. , Troitskaya T.I. , Trukhin D.V.
A combinatorially convenient version of synthesis of 5-substituted oxazole-4-carboxylic acid ethyl esters
Russian Journal of Organic Chemistry. 2006. V.42. N7. P.1031-1035. DOI: 10.1134/S1070428006070177 WOS Scopus РИНЦ

Тормышев В.М. , Михалина Т.В. , Рогожникова О.Ю. , Троицкая Т.И. , Трухин Д.В.
Удобный для применения в комбинаторной химии вариант синтеза этиловых эфиров 5-замещенных оксазол-4-карбоновых кислот
Журнал органической химии (RUSS J ORG CHEM+). 2006. Т.42. №7. С.1049-1053. РИНЦ

Published print:

Jul 1, 2006

Web of science	WOS:000240078600017
Scopus	2-s2.0-33747179597
Elibrary	13508389
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