A straightforward and convenient synthesis of Cbz-protected 2-(1-aminoalkyl)oxazole-5-carboxylates

A straightforward and convenient synthesis of Cbz-protected 2-(1-aminoalkyl)oxazole-5-carboxylates Full article

Journal

Synlett
ISSN: 0936-5214 , E-ISSN: 1437-2096

Output data

Year: 2005, Number: 13, Pages: 2072-2076 Pages count : 5 DOI: 10.1055/s-2005-871957

Tags

aminoalkyloxazolecarboxylates; peptide mimetics; combinatorial chemistry

Authors

Trukhin DV ¹ , Bagryanskaya IY ¹ , Gatilov YV ¹ , Mikhalina TV ¹ , Rogozhnikova OY ¹ , Troitskaya TI ¹ , Tormyshev VM ¹

Affiliations

1	(Данные Web of science) Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia

Cbz-protected 2-(1-aminoalkyl)oxazole-5-carboxylates are readily obtainable by a two-step enantioselective sequence involving reaction of benzyloxycarbonyl protected amino acids with alpha-chloro-beta-ketoesters and subsequent cyclization of the resulting acyloxyketones to required oxazoles upon treatment with neat ammonium trifluoacetate.

Trukhin D. , Bagryanskaya I. , Gatilov Y. , Mikhalina T. , Rogozhnikova O. , Troitskaya T. , Tormyshev V.
A straightforward and convenient synthesis of Cbz-protected 2-(1-aminoalkyl)oxazole-5-carboxylates
Synlett. 2005. N13. P.2072-2076. DOI: 10.1055/s-2005-871957 WOS Scopus РИНЦ

Web of science	WOS:000231457700021
Scopus	2-s2.0-23944526935
Elibrary	13487693
OpenAlex	W1994529782