A straightforward and convenient synthesis of Cbz-protected 2-(1-aminoalkyl)oxazole-5-carboxylates

A straightforward and convenient synthesis of Cbz-protected 2-(1-aminoalkyl)oxazole-5-carboxylates Научная публикация

Журнал

Synlett
ISSN: 0936-5214 , E-ISSN: 1437-2096

Вых. Данные

Год: 2005, Номер: 13, Страницы: 2072-2076 Страниц : 5 DOI: 10.1055/s-2005-871957

Ключевые слова

aminoalkyloxazolecarboxylates; peptide mimetics; combinatorial chemistry

Авторы

Trukhin DV ¹ , Bagryanskaya IY ¹ , Gatilov YV ¹ , Mikhalina TV ¹ , Rogozhnikova OY ¹ , Troitskaya TI ¹ , Tormyshev VM ¹

Организации

1	(Данные Web of science) Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia

Cbz-protected 2-(1-aminoalkyl)oxazole-5-carboxylates are readily obtainable by a two-step enantioselective sequence involving reaction of benzyloxycarbonyl protected amino acids with alpha-chloro-beta-ketoesters and subsequent cyclization of the resulting acyloxyketones to required oxazoles upon treatment with neat ammonium trifluoacetate.

Trukhin D. , Bagryanskaya I. , Gatilov Y. , Mikhalina T. , Rogozhnikova O. , Troitskaya T. , Tormyshev V.
A straightforward and convenient synthesis of Cbz-protected 2-(1-aminoalkyl)oxazole-5-carboxylates
Synlett. 2005. N13. P.2072-2076. DOI: 10.1055/s-2005-871957 WOS Scopus РИНЦ

Web of science	WOS:000231457700021
Scopus	2-s2.0-23944526935
РИНЦ	13487693
OpenAlex	W1994529782