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No Catalyst Added Hydrogen Peroxide Oxidation of Dextran: An Environmentally Friendly Route to Multifunctional Polymers Full article

Journal ACS Sustainable Chemistry and Engineering
ISSN: 2168-0485
Output data Year: 2020, Volume: 8, Number: 13, Pages: 5371-5379 Pages count : 9 DOI: 10.1021/acssuschemeng.0c01030
Tags Dextran polysaccharide; Hydrogen peroxide; Green oxidation; Functional groups; Cytotoxicity
Authors Pronina Ekaterina A. 1 , Vorotnikov Yuri A. 1 , Pozmogova Tatyana N. 2,3 , Solovieva Anastasiya O. 2 , Miroshnichenko Svetlana M. 2,4 , Plyusnin Pavel E. 1 , Pishchur Denis P. 1 , Eltsov Ilia, V 3 , Edeleva Mariya, V 5 , Shestopalov Michael A. 1 , Efremova Olga A. 2,4
Affiliations
1 (Данные Web of science) Nikolacv Inst Inorgan Chem SB RAS, Novosibirsk 630090, Russia
2 (Данные Web of science) ICG SB RAS, Res Inst Clin & Expt Lymphol, Novosibirsk 630060, Russia
3 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
4 (Данные Web of science) Fed Res Ctr Fundamental & Translat Med, Novosibirsk 630117, Russia
5 (Данные Web of science) NN Vorozhtsov Novosibirsk Inst Organ Chem SB RAS, Novosibirsk 630090, Russia

Abstract: The paper demonstrates a "greener" oxidation of dextran polymer of various molecular masses, the component of many industrially and pharmaceutically important materials, by aqueous H2O2 in a no catalyst added setting that produced a multifunctional oxidized dextran. Specifically, on the top of common functional groups (hydroxo, carbonyl, and carboxylic acids), the freshly peroxide oxidized dextran had also a significant number of peroxo-groups, which endowed the polymer with significant cytotoxic properties, as demonstrated on a larynx carcinoma cell line. We also have shown that the peroxo-groups could be easily removed in an alkaline media to yield nontoxic oxidized dextran polymers.
Cite: Pronina E.A. , Vorotnikov Y.A. , Pozmogova T.N. , Solovieva A.O. , Miroshnichenko S.M. , Plyusnin P.E. , Pishchur D.P. , Eltsov I.V. , Edeleva M.V. , Shestopalov M.A. , Efremova O.A.
No Catalyst Added Hydrogen Peroxide Oxidation of Dextran: An Environmentally Friendly Route to Multifunctional Polymers
ACS Sustainable Chemistry and Engineering. 2020. V.8. N13. P.5371-5379. DOI: 10.1021/acssuschemeng.0c01030 WOS Scopus РИНЦ
Dates:
Published online: Mar 16, 2020
Published print: Apr 6, 2020
Identifiers:
Web of science WOS:000526363600041
Scopus 2-s2.0-85083812766
Elibrary 43274147
OpenAlex W3010774075
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