No Catalyst Added Hydrogen Peroxide Oxidation of Dextran: An Environmentally Friendly Route to Multifunctional Polymers

No Catalyst Added Hydrogen Peroxide Oxidation of Dextran: An Environmentally Friendly Route to Multifunctional Polymers Научная публикация

Журнал

ACS Sustainable Chemistry and Engineering
ISSN: 2168-0485

Вых. Данные

Год: 2020, Том: 8, Номер: 13, Страницы: 5371-5379 Страниц : 9 DOI: 10.1021/acssuschemeng.0c01030

Ключевые слова

Dextran polysaccharide; Hydrogen peroxide; Green oxidation; Functional groups; Cytotoxicity

Авторы

Pronina Ekaterina A. ¹ , Vorotnikov Yuri A. ¹ , Pozmogova Tatyana N. ^2,3 , Solovieva Anastasiya O. ² , Miroshnichenko Svetlana M. ^2,4 , Plyusnin Pavel E. ¹ , Pishchur Denis P. ¹ , Eltsov Ilia, V ³ , Edeleva Mariya, V ⁵ , Shestopalov Michael A. ¹ , Efremova Olga A. ^2,4

Организации

1	(Данные Web of science) Nikolacv Inst Inorgan Chem SB RAS, Novosibirsk 630090, Russia
2	(Данные Web of science) ICG SB RAS, Res Inst Clin & Expt Lymphol, Novosibirsk 630060, Russia
3	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
4	(Данные Web of science) Fed Res Ctr Fundamental & Translat Med, Novosibirsk 630117, Russia
5	(Данные Web of science) NN Vorozhtsov Novosibirsk Inst Organ Chem SB RAS, Novosibirsk 630090, Russia

The paper demonstrates a "greener" oxidation of dextran polymer of various molecular masses, the component of many industrially and pharmaceutically important materials, by aqueous H2O2 in a no catalyst added setting that produced a multifunctional oxidized dextran. Specifically, on the top of common functional groups (hydroxo, carbonyl, and carboxylic acids), the freshly peroxide oxidized dextran had also a significant number of peroxo-groups, which endowed the polymer with significant cytotoxic properties, as demonstrated on a larynx carcinoma cell line. We also have shown that the peroxo-groups could be easily removed in an alkaline media to yield nontoxic oxidized dextran polymers.

Pronina E.A. , Vorotnikov Y.A. , Pozmogova T.N. , Solovieva A.O. , Miroshnichenko S.M. , Plyusnin P.E. , Pishchur D.P. , Eltsov I.V. , Edeleva M.V. , Shestopalov M.A. , Efremova O.A.
No Catalyst Added Hydrogen Peroxide Oxidation of Dextran: An Environmentally Friendly Route to Multifunctional Polymers
ACS Sustainable Chemistry and Engineering. 2020. V.8. N13. P.5371-5379. DOI: 10.1021/acssuschemeng.0c01030 WOS Scopus РИНЦ

Опубликована online:	16 мар. 2020 г.
Опубликована в печати:	6 апр. 2020 г.

Web of science	WOS:000526363600041
Scopus	2-s2.0-85083812766
РИНЦ	43274147
OpenAlex	W3010774075