In Vivo Stability of Polyurethane-Based Electrospun Vascular Grafts in Terms of Chemistry and Mechanics

In Vivo Stability of Polyurethane-Based Electrospun Vascular Grafts in Terms of Chemistry and Mechanics Full article

Journal

Polymers
ISSN: 2073-4360

Output data

Year: 2020, Volume: 12, Number: 4, Article number : 845, Pages count : DOI: 10.3390/polym12040845

Tags

tecoflex; pellethane; gelatin; electrospinning; vascular grafts; polyurethane stability in vivo

Authors

Gostev Alexander A. ¹ , Shundrina Inna K. ^2,3 , Pastukhov Vitaliy I. ^2,3 , Shutov Alexey V. ^3,5 , Chernonosova Vera S. ⁴ , Karpenko Andrey A. ¹ , Laktionov Pavel P. ^1,4

Affiliations

1	(Данные Web of science) Minist Hlth Russian Federat, Meshalkin Natl Med Res Ctr, Novosibirsk 630055, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Univ, Ul Pirogova 2, Novosibirsk 630090, Russia
4	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia
5	(Данные Web of science) Russian Acad Sci, Siberian Branch, Lavrentiev Inst Hydrodynam, Novosibirsk 630090, Russia

The biostability of the polyurethanes Tecoflex EG-80A and Pellethane 2363-80A, used as basic polymers of the vascular grafts (VGs) produced by electrospinning, as well as the tensile strength of Tecoflex VGs, are studied. Solutions of Tecoflex or Pellethane with gelatin and bivalirudin in 1,1,1,3,3,3-hexafluoroisopropanol are used for VG production. After 1, 12, and 24 weeks of VG implantation in the infrarenal position of the abdominal aorta of Wistar rats, VGs are explanted, fixed in formalin, freed from outer tissues, dialyzed, and dried. The polyurethanes are extracted from VGs by dispersion/extraction in tetrahydrofuran (THF) and freed from the excess of THF-insoluble biopolymers. The stability of polyurethanes is assessed by IR spectroscopy and gel permeation chromatography. Pellethane has emerged to be stable at all experimental points. Tecoflex loses approximately 10% of its molecular weight (both M-n and M-w) after 3 months and restored its initial value within 6 months of its functioning as a graft. Mechanical testing demonstrates a 30% reduction in the tensile strength after 3 months in VG and a 10% increase after 6 months. The stability and mechanical properties of polyurethane-based VGs demonstrate their utility for the reconstitution of damaged arteries.

Gostev A.A. , Shundrina I.K. , Pastukhov V.I. , Shutov A.V. , Chernonosova V.S. , Karpenko A.A. , Laktionov P.P.
In Vivo Stability of Polyurethane-Based Electrospun Vascular Grafts in Terms of Chemistry and Mechanics

Polymers. 2020. V.12. N4. 845 . DOI: 10.3390/polym12040845 WOS Scopus РИНЦ

Full text from publisher

Published online:

Apr 7, 2020

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