Synthesis and inhibitory effect on platelet aggregation and antihypertensive activity of 1-hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides, 1,3-dihydroxyimidazolidine-2-carboxylic acids, and 1,4-dihydroxy-2,3-piperazinediones

Synthesis and inhibitory effect on platelet aggregation and antihypertensive activity of 1-hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides, 1,3-dihydroxyimidazolidine-2-carboxylic acids, and 1,4-dihydroxy-2,3-piperazinediones Full article

Journal

Archiv der Pharmazie
ISSN: 0365-6233

Output data

Year: 1999, Volume: 332, Number: 9, Pages: 305-308 Pages count : 4 DOI: 10.1002/(SICI)1521-4184(19999)332:9<305::AID-ARDP305>3.0.CO;2-2

Tags

Imidazolidine-2-carboxylic acids; 2,5-dihydro-1H-imidazole-2-carboxylic acids; 1,4-dihydroxy-2,3-piperazinediones; platelet aggregation; antihypertensive activity

Authors

Tikhonov Aleksei Ya. ¹ , Mazhukin Dmitrii G. ¹ , Grigor'eva Larisa N. ² , Khlestkin Vadim K. ¹ , Voinova Natal′ya N. ² , Syropyatov B.oris Ya. ³ , Shirinkina Svetlana S. ³ , Volodarsky Leonid B. ¹

Affiliations

1	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
2	Novosibirsk State University
3	Perm Pharmaceutical Academy, Perm 614600, Lenina str., 48, Russia

The reaction of 1,2-hydroxylamino-oximes 1 with pyruvic or glyoxylic acid and of 1,2-bishydroxylamines 4 with glyoxylic acid resulted in 2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides 2 and 2-imidazolidinecarboxylic acids 5, respectively. It was found that hydroxylamino acids 2 and 1,4-dihydroxy-2,3-piperazinediones 7 showed marked inhibitory effect on platelet aggregation. 1-Hydroxy-2-methyl-1,5,6,7,8,8a-hexahydro-2H,4H-cycloheptimidazole- 2-carboxylic acid 3-oxide 2e exhibited antihypertensive activity.

Tikhonov A.Y. , Mazhukin D.G. , Grigor'eva L.N. , Khlestkin V.K. , Voinova N.N. , Syropyatov B.o.Y. , Shirinkina S.S. , Volodarsky L.B.
Synthesis and inhibitory effect on platelet aggregation and antihypertensive activity of 1-hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides, 1,3-dihydroxyimidazolidine-2-carboxylic acids, and 1,4-dihydroxy-2,3-piperazinediones
Archiv der Pharmazie. 1999. V.332. N9. P.305-308. DOI: 10.1002/(SICI)1521-4184(19999)332:9<305::AID-ARDP305>3.0.CO;2-2 WOS Scopus РИНЦ

Published print:

Sep 1, 1999

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