Synthesis and inhibitory effect on platelet aggregation and antihypertensive activity of 1-hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides, 1,3-dihydroxyimidazolidine-2-carboxylic acids, and 1,4-dihydroxy-2,3-piperazinediones

Synthesis and inhibitory effect on platelet aggregation and antihypertensive activity of 1-hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides, 1,3-dihydroxyimidazolidine-2-carboxylic acids, and 1,4-dihydroxy-2,3-piperazinediones Научная публикация

Журнал

Archiv der Pharmazie
ISSN: 0365-6233

Вых. Данные

Год: 1999, Том: 332, Номер: 9, Страницы: 305-308 Страниц : 4 DOI: 10.1002/(SICI)1521-4184(19999)332:9<305::AID-ARDP305>3.0.CO;2-2

Ключевые слова

Imidazolidine-2-carboxylic acids; 2,5-dihydro-1H-imidazole-2-carboxylic acids; 1,4-dihydroxy-2,3-piperazinediones; platelet aggregation; antihypertensive activity

Авторы

Tikhonov Aleksei Ya. ¹ , Mazhukin Dmitrii G. ¹ , Grigor'eva Larisa N. ² , Khlestkin Vadim K. ¹ , Voinova Natal′ya N. ² , Syropyatov B.oris Ya. ³ , Shirinkina Svetlana S. ³ , Volodarsky Leonid B. ¹

Организации

1	Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАН
2	Новосибирский национальный исследовательский государственный университет
3	Perm Pharmaceutical Academy, Perm 614600, Lenina str., 48, Russia

The reaction of 1,2-hydroxylamino-oximes 1 with pyruvic or glyoxylic acid and of 1,2-bishydroxylamines 4 with glyoxylic acid resulted in 2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides 2 and 2-imidazolidinecarboxylic acids 5, respectively. It was found that hydroxylamino acids 2 and 1,4-dihydroxy-2,3-piperazinediones 7 showed marked inhibitory effect on platelet aggregation. 1-Hydroxy-2-methyl-1,5,6,7,8,8a-hexahydro-2H,4H-cycloheptimidazole- 2-carboxylic acid 3-oxide 2e exhibited antihypertensive activity.

Tikhonov A.Y. , Mazhukin D.G. , Grigor'eva L.N. , Khlestkin V.K. , Voinova N.N. , Syropyatov B.o.Y. , Shirinkina S.S. , Volodarsky L.B.
Synthesis and inhibitory effect on platelet aggregation and antihypertensive activity of 1-hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides, 1,3-dihydroxyimidazolidine-2-carboxylic acids, and 1,4-dihydroxy-2,3-piperazinediones
Archiv der Pharmazie. 1999. V.332. N9. P.305-308. DOI: 10.1002/(SICI)1521-4184(19999)332:9<305::AID-ARDP305>3.0.CO;2-2 WOS Scopus РИНЦ

Опубликована в печати:

1 сент. 1999 г.

Web of science	WOS:000082603200002
Scopus	2-s2.0-0032879455
РИНЦ	13313373
OpenAlex	W2097555251