Preparation of 2,6-difluoro-n-alkylbenzenes from 1,3-difluorobenzene transformation of 2,6-difluorotoluene to the corresponding benzaldehyde via benzyl chloride Full article
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Journal of Fluorine Chemistry
ISSN: 0022-1139 |
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Output data | Year: 1998, Volume: 91, Number: 1, Pages: 19-20 Pages count : 2 DOI: 10.1016/S0022-1139(98)00199-7 | ||
Tags | 2,6-difluoro-n-alkylbenzene; alkylation; chlorination; 2,6-difluorophenyl derivatives; liquid ammonia | ||
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Abstract:
Reactions of n-alkyl chlorides with the 2,6-difluorophenyl anion prepared from 1,3-difluorobenzene by the action of sodium amide in liquid ammonia give 2,6-difluoro-n-alkylbenzenes in high yields. 2,6-Difluorotoluene reacts with chlorine at 80 degrees C to give 2,6-difluorobenzyl chloride in 92% yield. 2,6-Difluorobenzaldehyde has been obtained from this chloride through Sommelet's reaction in 62% yield. (C) 1998 Elsevier Science S.A. All rights reserved.
Cite:
Malykhin E.V.
, Shteingarts V.D.
Preparation of 2,6-difluoro-n-alkylbenzenes from 1,3-difluorobenzene transformation of 2,6-difluorotoluene to the corresponding benzaldehyde via benzyl chloride
Journal of Fluorine Chemistry. 1998. V.91. N1. P.19-20. DOI: 10.1016/S0022-1139(98)00199-7 WOS Scopus
Preparation of 2,6-difluoro-n-alkylbenzenes from 1,3-difluorobenzene transformation of 2,6-difluorotoluene to the corresponding benzaldehyde via benzyl chloride
Journal of Fluorine Chemistry. 1998. V.91. N1. P.19-20. DOI: 10.1016/S0022-1139(98)00199-7 WOS Scopus
Dates:
Published print: | Aug 1, 1998 |
Identifiers:
Web of science | WOS:000075497400005 |
Scopus | 2-s2.0-0032504417 |
OpenAlex | W2066289238 |