Preparation of 2,6-difluoro-n-alkylbenzenes from 1,3-difluorobenzene transformation of 2,6-difluorotoluene to the corresponding benzaldehyde via benzyl chloride

Preparation of 2,6-difluoro-n-alkylbenzenes from 1,3-difluorobenzene transformation of 2,6-difluorotoluene to the corresponding benzaldehyde via benzyl chloride Научная публикация

Журнал

Journal of Fluorine Chemistry
ISSN: 0022-1139

Вых. Данные

Год: 1998, Том: 91, Номер: 1, Страницы: 19-20 Страниц : 2 DOI: 10.1016/S0022-1139(98)00199-7

Ключевые слова

2,6-difluoro-n-alkylbenzene; alkylation; chlorination; 2,6-difluorophenyl derivatives; liquid ammonia

Авторы

Malykhin Evghenii V. ¹ , Shteingarts Vitalii D. ¹

Организации

1	N.N, Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences; Lavrentiev ave. 9, Novosibirsk 630090, Russian Federation, Russia

Reactions of n-alkyl chlorides with the 2,6-difluorophenyl anion prepared from 1,3-difluorobenzene by the action of sodium amide in liquid ammonia give 2,6-difluoro-n-alkylbenzenes in high yields. 2,6-Difluorotoluene reacts with chlorine at 80 degrees C to give 2,6-difluorobenzyl chloride in 92% yield. 2,6-Difluorobenzaldehyde has been obtained from this chloride through Sommelet's reaction in 62% yield. (C) 1998 Elsevier Science S.A. All rights reserved.

Malykhin E.V. , Shteingarts V.D.
Preparation of 2,6-difluoro-n-alkylbenzenes from 1,3-difluorobenzene transformation of 2,6-difluorotoluene to the corresponding benzaldehyde via benzyl chloride
Journal of Fluorine Chemistry. 1998. V.91. N1. P.19-20. DOI: 10.1016/S0022-1139(98)00199-7 WOS Scopus

Опубликована в печати:

1 авг. 1998 г.

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