Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (-)-Borneol from Abies sibirica and (+)-Camphor

Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (-)-Borneol from Abies sibirica and (+)-Camphor Full article

Journal

Chemistry and Biodiversity
ISSN: 1612-1872 , E-ISSN: 1612-1880

Output data

Year: 2018, Volume: 15, Number: 9, Article number : e1800153, Pages count : DOI: 10.1002/cbdv.201800153

Tags

borneol; N-heterocycles; antiviral activities; orthopoxviruses; monoterpenoids

Authors

Sokolova Anastasiya S. ¹ , Yarovaya Olga I. ^1,2 , Bormotov Nikolay I. ³ , Shishkina Larisa N. ³ , Salakhutdinov Nariman F. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, Dept Med Chem, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Lavrentev Ave, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Lab New Med, 2 Pirogova St, Novosibirsk 630090, Russia
3	(Данные Web of science) State Res Ctr Virol & Biotechnol Vector, Dept Prevent & Treatment Especially Dangerous Inf, Koltsov 630559, Novosibirsk Reg, Russia

A series of the bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 m, respectively, and good cytotoxicity. The primary structure-activity relationship (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.

Sokolova A.S. , Yarovaya O.I. , Bormotov N.I. , Shishkina L.N. , Salakhutdinov N.F.
Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (-)-Borneol from Abies sibirica and (+)-Camphor
Chemistry and Biodiversity. 2018. V.15. N9. e1800153 . DOI: 10.1002/cbdv.201800153 WOS Scopus РИНЦ

Published online:	Aug 9, 2018
Published print:	Sep 1, 2018

Web of science	WOS:000444576900002
Scopus	2-s2.0-85052525434
Elibrary	35789749
OpenAlex	W2809879292