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Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (-)-Borneol from Abies sibirica and (+)-Camphor Научная публикация

Журнал Chemistry and Biodiversity
ISSN: 1612-1872 , E-ISSN: 1612-1880
Вых. Данные Год: 2018, Том: 15, Номер: 9, Номер статьи : e1800153, Страниц : DOI: 10.1002/cbdv.201800153
Ключевые слова borneol; N-heterocycles; antiviral activities; orthopoxviruses; monoterpenoids
Авторы Sokolova Anastasiya S. 1 , Yarovaya Olga I. 1,2 , Bormotov Nikolay I. 3 , Shishkina Larisa N. 3 , Salakhutdinov Nariman F. 1,2
Организации
1 (Данные Web of science) Russian Acad Sci, Dept Med Chem, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Lavrentev Ave, Novosibirsk 630090, Russia
2 (Данные Web of science) Novosibirsk State Univ, Lab New Med, 2 Pirogova St, Novosibirsk 630090, Russia
3 (Данные Web of science) State Res Ctr Virol & Biotechnol Vector, Dept Prevent & Treatment Especially Dangerous Inf, Koltsov 630559, Novosibirsk Reg, Russia

Реферат: A series of the bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 m, respectively, and good cytotoxicity. The primary structure-activity relationship (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.
Библиографическая ссылка: Sokolova A.S. , Yarovaya O.I. , Bormotov N.I. , Shishkina L.N. , Salakhutdinov N.F.
Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (-)-Borneol from Abies sibirica and (+)-Camphor
Chemistry and Biodiversity. 2018. V.15. N9. e1800153 . DOI: 10.1002/cbdv.201800153 WOS Scopus РИНЦ
Даты:
Опубликована online: 9 авг. 2018 г.
Опубликована в печати: 1 сент. 2018 г.
Идентификаторы:
Web of science WOS:000444576900002
Scopus 2-s2.0-85052525434
РИНЦ 35789749
OpenAlex W2809879292
Альметрики: