SYNTHESIS AND INHIBITORY PROPERTIES OF IMINES CONTAINING MONOTERPENOID AND ADAMANTANE FRAGMENTS AGAINST DNA REPAIR ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)

SYNTHESIS AND INHIBITORY PROPERTIES OF IMINES CONTAINING MONOTERPENOID AND ADAMANTANE FRAGMENTS AGAINST DNA REPAIR ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1) Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2018, Volume: 54, Number: 4, Pages: 672-676 Pages count : 5 DOI: 10.1007/s10600-018-2443-7

Tags

adamantane; monoterpene; tyrosyl-DNA phosphodiesterase 1; DNA repair inhibitor; Schiff base

Authors

Zakharenko A.L. ¹ , Mozhaitsev E.S. ² , Suslov E.V. ² , Korchagina D.V. ² , Volcho K.P. ^2,3 , Salakhutdinov N.F. ^2,3 , Lavrik O.I. ^1,3

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, 8 Prosp Acad Lavrenteva, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Acad Lavrenteva, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Univ, 2 Pirogova St, Novosibirsk 630090, Russia

Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5-7.1 mu M.

Zakharenko A.L. , Mozhaitsev E.S. , Suslov E.V. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F. , Lavrik O.I.
SYNTHESIS AND INHIBITORY PROPERTIES OF IMINES CONTAINING MONOTERPENOID AND ADAMANTANE FRAGMENTS AGAINST DNA REPAIR ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)
Chemistry of Natural Compounds. 2018. V.54. N4. P.672-676. DOI: 10.1007/s10600-018-2443-7 WOS Scopus РИНЦ

Published print:	Jul 1, 2018
Published online:	Jul 25, 2018

Web of science	WOS:000440423000013
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Elibrary	35754948
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