SYNTHESIS AND INHIBITORY PROPERTIES OF IMINES CONTAINING MONOTERPENOID AND ADAMANTANE FRAGMENTS AGAINST DNA REPAIR ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)

SYNTHESIS AND INHIBITORY PROPERTIES OF IMINES CONTAINING MONOTERPENOID AND ADAMANTANE FRAGMENTS AGAINST DNA REPAIR ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1) Научная публикация

Журнал

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Вых. Данные

Год: 2018, Том: 54, Номер: 4, Страницы: 672-676 Страниц : 5 DOI: 10.1007/s10600-018-2443-7

Ключевые слова

adamantane; monoterpene; tyrosyl-DNA phosphodiesterase 1; DNA repair inhibitor; Schiff base

Авторы

Zakharenko A.L. ¹ , Mozhaitsev E.S. ² , Suslov E.V. ² , Korchagina D.V. ² , Volcho K.P. ^2,3 , Salakhutdinov N.F. ^2,3 , Lavrik O.I. ^1,3

Организации

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, 8 Prosp Acad Lavrenteva, Novosibirsk 630090, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Acad Lavrenteva, Novosibirsk 630090, Russia
3	(Данные Web of science) Novosibirsk State Univ, 2 Pirogova St, Novosibirsk 630090, Russia

Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5-7.1 mu M.

Zakharenko A.L. , Mozhaitsev E.S. , Suslov E.V. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F. , Lavrik O.I.
SYNTHESIS AND INHIBITORY PROPERTIES OF IMINES CONTAINING MONOTERPENOID AND ADAMANTANE FRAGMENTS AGAINST DNA REPAIR ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)
Chemistry of Natural Compounds. 2018. V.54. N4. P.672-676. DOI: 10.1007/s10600-018-2443-7 WOS Scopus РИНЦ

Опубликована в печати:	1 июл. 2018 г.
Опубликована online:	25 июл. 2018 г.

Web of science	WOS:000440423000013
Scopus	2-s2.0-85050668291
РИНЦ	35754948
OpenAlex	W2883821358