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Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo Full article

Journal Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888
Output data Year: 2017, Volume: 164, Number: 1, Pages: 49-53 Pages count : 5 DOI: 10.1007/s10517-017-3924-6
Tags alkoxyamines; toxicity; tumor cell lines; transplanted tumor strains; phagocytic activity of peritoneal macrophages
Authors Popova N.A. 1 , Sysoeva G.M. 2 , Nikolin V.P. 1 , Kaledin V.I. 1 , Tretyakov E.V. 3 , Edeeva M.V. 3 , Balakhnin S.M. 4 , Lushnikova E.L. 4 , Audran G. 5 , Mark S. 3
Affiliations
1 (Данные Web of science) Russian Acad Sci, Fed Res Inst Cytol & Genet, Siberian Div, Novosibirsk, Russia
2 (Данные Web of science) Vektor State Res Ctr Virol & Biotechnol, Inst Med Biotechnol, Koltsov, Novosibirsk Reg, Russia
3 (Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Div, Moscow, Russia
4 (Данные Web of science) Inst Mol Pathol & Pathomorphol, Novosibirsk, Russia
5 (Данные Web of science) Aix Marseille Univ, Aix En Provence, France

Abstract: Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.
Cite: Popova N.A. , Sysoeva G.M. , Nikolin V.P. , Kaledin V.I. , Tretyakov E.V. , Edeeva M.V. , Balakhnin S.M. , Lushnikova E.L. , Audran G. , Mark S.
Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo
Bulletin of Experimental Biology and Medicine. 2017. V.164. N1. P.49-53. DOI: 10.1007/s10517-017-3924-6 WOS Scopus РИНЦ
ArticleLinkType.TRANSLATED_TO_ORIGINAL: Низомов С.А. , Сорокина И.В. , Жукова Н.А. , Толстикова Т.Г. , Семенов Д.Е. , Просенко А.Е.
Сравнительное исследование токсичности алкоксиаминов in vitro и in vivo
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2017. Т.164. №7. С.61-65. РИНЦ
Dates:
Published print: Nov 1, 2017
Published online: Nov 9, 2017
Identifiers:
Web of science WOS:000415613100013
Scopus 2-s2.0-85033378169
Elibrary 31044534
OpenAlex W2767556561
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