Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo

Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo Научная публикация

Журнал

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Вых. Данные

Год: 2017, Том: 164, Номер: 1, Страницы: 49-53 Страниц : 5 DOI: 10.1007/s10517-017-3924-6

Ключевые слова

alkoxyamines; toxicity; tumor cell lines; transplanted tumor strains; phagocytic activity of peritoneal macrophages

Авторы

Popova N.A. ¹ , Sysoeva G.M. ² , Nikolin V.P. ¹ , Kaledin V.I. ¹ , Tretyakov E.V. ³ , Edeeva M.V. ³ , Balakhnin S.M. ⁴ , Lushnikova E.L. ⁴ , Audran G. ⁵ , Mark S. ³

Организации

1	(Данные Web of science) Russian Acad Sci, Fed Res Inst Cytol & Genet, Siberian Div, Novosibirsk, Russia
2	(Данные Web of science) Vektor State Res Ctr Virol & Biotechnol, Inst Med Biotechnol, Koltsov, Novosibirsk Reg, Russia
3	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Div, Moscow, Russia
4	(Данные Web of science) Inst Mol Pathol & Pathomorphol, Novosibirsk, Russia
5	(Данные Web of science) Aix Marseille Univ, Aix En Provence, France

Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.

Popova N.A. , Sysoeva G.M. , Nikolin V.P. , Kaledin V.I. , Tretyakov E.V. , Edeeva M.V. , Balakhnin S.M. , Lushnikova E.L. , Audran G. , Mark S.
Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo
Bulletin of Experimental Biology and Medicine. 2017. V.164. N1. P.49-53. DOI: 10.1007/s10517-017-3924-6 WOS Scopus РИНЦ

Низомов С.А. , Сорокина И.В. , Жукова Н.А. , Толстикова Т.Г. , Семенов Д.Е. , Просенко А.Е.
Сравнительное исследование токсичности алкоксиаминов in vitro и in vivo
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2017. Т.164. №7. С.61-65. РИНЦ

Опубликована в печати:	1 нояб. 2017 г.
Опубликована online:	9 нояб. 2017 г.

Web of science	WOS:000415613100013
Scopus	2-s2.0-85033378169
РИНЦ	31044534
OpenAlex	W2767556561