Analgesic properties of new pyrrolidinomorphinane derivatives: Revealing potential pathways

Analgesic properties of new pyrrolidinomorphinane derivatives: Revealing potential pathways Full article

Journal

Natural Product Communications
ISSN: 1934-578X , E-ISSN: 1555-9475

Output data

Year: 2008, Volume: 3, Number: 10, Pages: 1621-1624 Pages count : 4 DOI: 10.1177/1934578x0800301008

Tags

Analgesic; Anti-inflammatory activity; Naloxone; Pyrrolidinomorphinane derivatives

Authors

Morozova E.A. ¹ , Tolstikova T.G. ¹ , Bolkunov A.V. ¹ , Dolgikh M.P. ¹ , Shul'ts E.E. ¹

Affiliations

1	(Scopus) Laboratory of Pharmacological Research, N.N. Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Av., 9, 630090, Novosibirsk, Russian Federation

The pyrrolidinomorphinane derivatives have been found to be active in the writhing tests in mice with the analgesic effect being antagonized by naloxone. This suggests that analgesia is mediated by the opioid system. The compounds also displayed anti-inflammatory activity in formalin and histamine edema experimental models and the data may be evidence for antiinflammatory activity involvement in the inhibition of pain reaction.

Morozova E.A. , Tolstikova T.G. , Bolkunov A.V. , Dolgikh M.P. , Shul'ts E.E.
Analgesic properties of new pyrrolidinomorphinane derivatives: Revealing potential pathways

Natural Product Communications. 2008. V.3. N10. P.1621-1624. DOI: 10.1177/1934578x0800301008 Scopus

Full text from publisher

Published print:	Oct 1, 2008
Published online:	Oct 1, 2008

Scopus	2-s2.0-77954092952
OpenAlex	W2928640977