Analgesic properties of new pyrrolidinomorphinane derivatives: Revealing potential pathways

Analgesic properties of new pyrrolidinomorphinane derivatives: Revealing potential pathways Научная публикация

Журнал

Natural Product Communications
ISSN: 1934-578X , E-ISSN: 1555-9475

Вых. Данные

Год: 2008, Том: 3, Номер: 10, Страницы: 1621-1624 Страниц : 4 DOI: 10.1177/1934578x0800301008

Ключевые слова

Analgesic; Anti-inflammatory activity; Naloxone; Pyrrolidinomorphinane derivatives

Авторы

Morozova E.A. ¹ , Tolstikova T.G. ¹ , Bolkunov A.V. ¹ , Dolgikh M.P. ¹ , Shul'ts E.E. ¹

Организации

1	(Scopus) Laboratory of Pharmacological Research, N.N. Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Av., 9, 630090, Novosibirsk, Russian Federation

The pyrrolidinomorphinane derivatives have been found to be active in the writhing tests in mice with the analgesic effect being antagonized by naloxone. This suggests that analgesia is mediated by the opioid system. The compounds also displayed anti-inflammatory activity in formalin and histamine edema experimental models and the data may be evidence for antiinflammatory activity involvement in the inhibition of pain reaction.

Morozova E.A. , Tolstikova T.G. , Bolkunov A.V. , Dolgikh M.P. , Shul'ts E.E.
Analgesic properties of new pyrrolidinomorphinane derivatives: Revealing potential pathways

Natural Product Communications. 2008. V.3. N10. P.1621-1624. DOI: 10.1177/1934578x0800301008 Scopus

Полный текст от издателя

Опубликована в печати:	1 окт. 2008 г.
Опубликована online:	1 окт. 2008 г.

Scopus	2-s2.0-77954092952
OpenAlex	W2928640977