Abstract: Several polymorphs of solvates of furosemide with dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) have been obtained, and their crystal structures were solved and analyzed. The structures differ from each other in both conformation of the furosemide molecule (particularly with respect to the orientation of the furanylmethylamino fragment) and molecular packing. The arrangement of solvent molecules-DMSO and DMF-is different in different polymorphs: either in the channels or between the layers. Layered polymorphs can be formed on rapid crystallization using water as an antisolvent, whereas a slower crystallization on evaporation promotes the growth of channeled structures. Despite different crystal structures, F-DMSO-I, F-DMSO-II, F-DMSO-III, and F-DMF-II give the same phase on desolvation, namely, furosemide polymorph I, which is the thermodynamic form at ambient conditions.

Cite: Beloborodova A.A. , Minkov V.S. , Rychkov D.A. , Rybalova T.V. , Boldyreva E.V.
First Evidence of Polymorphism in Furosemide Solvates
Crystal Growth and Design. 2017. V.17. N5. P.2333-2341. DOI: 10.1021/acs.cgd.6b01191 WOS Scopus

Dates:

Published online:	Mar 29, 2017
Published print:	May 3, 2017

Identifiers:

Web of science	WOS:000400802500006
Scopus	2-s2.0-85018979750
OpenAlex	W2598497561

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