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First Evidence of Polymorphism in Furosemide Solvates Научная публикация

Журнал Crystal Growth and Design
ISSN: 1528-7483 , E-ISSN: 1528-7505
Вых. Данные Год: 2017, Том: 17, Номер: 5, Страницы: 2333-2341 Страниц : 9 DOI: 10.1021/acs.cgd.6b01191
Авторы Beloborodova Alina A. 1,2 , Minkov Vasily S. 3 , Rychkov Denis A. 1 , Rybalova Tatyana V. 1,2 , Boldyreva Elena V. 1,4
Организации
1 (Данные Web of science) Novosibirsk State Univ, Novosibirsk, Russia
2 (Данные Web of science) SB RAS, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk, Russia
3 (Данные Web of science) Max Planck Inst Chem, Hahn Meitner Weg 1, Mainz, Germany
4 (Данные Web of science) SB RAS, Inst Solid State Chem & Mechanochem, Novosibirsk, Russia

Реферат: Several polymorphs of solvates of furosemide with dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) have been obtained, and their crystal structures were solved and analyzed. The structures differ from each other in both conformation of the furosemide molecule (particularly with respect to the orientation of the furanylmethylamino fragment) and molecular packing. The arrangement of solvent molecules-DMSO and DMF-is different in different polymorphs: either in the channels or between the layers. Layered polymorphs can be formed on rapid crystallization using water as an antisolvent, whereas a slower crystallization on evaporation promotes the growth of channeled structures. Despite different crystal structures, F-DMSO-I, F-DMSO-II, F-DMSO-III, and F-DMF-II give the same phase on desolvation, namely, furosemide polymorph I, which is the thermodynamic form at ambient conditions.
Библиографическая ссылка: Beloborodova A.A. , Minkov V.S. , Rychkov D.A. , Rybalova T.V. , Boldyreva E.V.
First Evidence of Polymorphism in Furosemide Solvates
Crystal Growth and Design. 2017. V.17. N5. P.2333-2341. DOI: 10.1021/acs.cgd.6b01191 WOS Scopus
Даты:
Опубликована online: 29 мар. 2017 г.
Опубликована в печати: 3 мая 2017 г.
Идентификаторы:
Web of science WOS:000400802500006
Scopus 2-s2.0-85018979750
OpenAlex W2598497561
Альметрики: