Biophotonics approach for the study of leukocyte activation Full article
Conference |
Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine 23-27 Sep 2019 , Saratov |
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Journal |
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN: 1605-7422 |
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Output data | Year: 2020, Volume: 11457, Article number : 114570G, Pages count : DOI: 10.1117/12.2560325 | ||||||||
Tags | Arachidonic acid; Biophotonics; Caged arachidonic acid; Dysfunction of leukocytes; Intracellular calcium; Jurkat cell; Photolabile analogs; Single cell optical control | ||||||||
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Abstract:
Leukocytes are the main cells of immune system, but also contribute to other systems and participate in pathogenesis of different diseases. In particular, leukocytes are involved in the progression of diabetic retinopathy due to their hyperactivation in diabetes. However, a connection between diabetes and the dysfunction of leukocytes is poorly understood. For a more complete picture, studies of the leukocytes activation under the influence of various substances are necessary. Arachidonic acid (AA) and its metabolites are the strongest activating factors of leukocytes. However, the studies involving AA are complicated because it is water-insoluble. Here we describe the method to study activation using photolabile analogs of AA. © 2020 SPIE.
Cite:
Chernova D.N.
, Sokolovski S.G.
, Vorobev A.Y.
, Moskalensky A.E.
Biophotonics approach for the study of leukocyte activation
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2020. V.11457. 114570G . DOI: 10.1117/12.2560325 WOS Scopus РИНЦ
Biophotonics approach for the study of leukocyte activation
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2020. V.11457. 114570G . DOI: 10.1117/12.2560325 WOS Scopus РИНЦ
Files:
Full text from publisher
Dates:
Published print: | Apr 9, 2020 |
Identifiers:
Web of science | WOS:000576665300015 |
Scopus | 2-s2.0-85084173115 |
Elibrary | 43277277 |
OpenAlex | W3015485730 |