Biophotonics approach for the study of leukocyte activation

Biophotonics approach for the study of leukocyte activation Научная публикация

Конференция

Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine
23-27 сент. 2019 , Saratov

Журнал

Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN: 1605-7422

Вых. Данные

Год: 2020, Том: 11457, Номер статьи : 114570G, Страниц : DOI: 10.1117/12.2560325

Ключевые слова

Arachidonic acid; Biophotonics; Caged arachidonic acid; Dysfunction of leukocytes; Intracellular calcium; Jurkat cell; Photolabile analogs; Single cell optical control

Авторы

Chernova D.N. ¹ , Sokolovski S.G. ^1,2 , Vorobev A.Y. ^1,3 , Moskalensky A.E. ^1,4

Организации

1	(Scopus) Novosibirsk State University, Pirogova str. 2, Novosibirsk, 630090, Russian Federation
2	(Scopus) Aston University, Aston Triangle, Birmingham, B4 7ET, United Kingdom
3	(Scopus) N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 9 Lavrentiev Avenue, Novosibirsk, 630090, Russian Federation
4	(Scopus) Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, Institutskaya 3, Novosibirsk, 630090, Russian Federation

Leukocytes are the main cells of immune system, but also contribute to other systems and participate in pathogenesis of different diseases. In particular, leukocytes are involved in the progression of diabetic retinopathy due to their hyperactivation in diabetes. However, a connection between diabetes and the dysfunction of leukocytes is poorly understood. For a more complete picture, studies of the leukocytes activation under the influence of various substances are necessary. Arachidonic acid (AA) and its metabolites are the strongest activating factors of leukocytes. However, the studies involving AA are complicated because it is water-insoluble. Here we describe the method to study activation using photolabile analogs of AA. © 2020 SPIE.

Chernova D.N. , Sokolovski S.G. , Vorobev A.Y. , Moskalensky A.E.
Biophotonics approach for the study of leukocyte activation

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2020. V.11457. 114570G . DOI: 10.1117/12.2560325 WOS Scopus РИНЦ

Полный текст от издателя

Опубликована в печати:

9 апр. 2020 г.

Web of science	WOS:000576665300015
Scopus	2-s2.0-85084173115
РИНЦ	43277277
OpenAlex	W3015485730