Abstract: Adequate treatment of Parkinson's disease is an important medical issue. Patients are suffered from numerous side effects of the widely used drugs. It has been found recently that monoterpenoid (1R, 2R, 6S)-3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol and its diacetate demonstrate high antiparkinsonian activity in some animal models. At the same time, their genetic safety was not studied yet. The aim of this research was to investigate the effect of these compounds with antiparkinsonian activities on reproduction of D. melanogaster. Over 4000 of fruitflies cultivated under the action of these compounds were analyzed. It was found that the chemicals did not provoke genetic mutations or alter reproduction of D. melanogaster. The possible explanations for the detected phenomena are provided. It was found that the compounds do not affect fertility in Drosophila..

Cite: Trushin M.V. , Khamidullina R.G. , Ardashov O.V. , Volcho K.P. , Salakhutdinov N.F.
The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster
Marmara Pharmaceutical Journal. 2017. V.21. N4. P.987-991. DOI: 10.12991/mpj.2017.29 WOS Scopus РИНЦ

Files: Full text from publisher

Dates:

Published print:

Oct 3, 2017

Identifiers:

Web of science	WOS:000417369600030
Scopus	2-s2.0-85031402849
Elibrary	31101672
OpenAlex	W2763292560

Altmetrics: