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The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster Научная публикация

Журнал Marmara Pharmaceutical Journal
ISSN: 1309-0801
Вых. Данные Год: 2017, Том: 21, Номер: 4, Страницы: 987-991 Страниц : 5 DOI: 10.12991/mpj.2017.29
Ключевые слова Parkinson's disease; fertility; drosophila; (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol; acetate; terpene
Авторы Trushin Maxim V. 1 , Khamidullina Raisa G. 1 , Ardashov Oleg V. 2 , Volcho Konstantin P. 2 , Salakhutdinov Nariman F. 2
Организации
1 (Данные Web of science) Kazan Fed Univ, Inst Fundamental Med & Biol, Kremlyovskaya 18, Kazan 420008, Russia
2 (Данные Web of science) Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Branch, Lavrentjev Ave 9, Novosibirsk 630090, Russia

Реферат: Adequate treatment of Parkinson's disease is an important medical issue. Patients are suffered from numerous side effects of the widely used drugs. It has been found recently that monoterpenoid (1R, 2R, 6S)-3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol and its diacetate demonstrate high antiparkinsonian activity in some animal models. At the same time, their genetic safety was not studied yet. The aim of this research was to investigate the effect of these compounds with antiparkinsonian activities on reproduction of D. melanogaster. Over 4000 of fruitflies cultivated under the action of these compounds were analyzed. It was found that the chemicals did not provoke genetic mutations or alter reproduction of D. melanogaster. The possible explanations for the detected phenomena are provided. It was found that the compounds do not affect fertility in Drosophila..
Библиографическая ссылка: Trushin M.V. , Khamidullina R.G. , Ardashov O.V. , Volcho K.P. , Salakhutdinov N.F.
The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster
Marmara Pharmaceutical Journal. 2017. V.21. N4. P.987-991. DOI: 10.12991/mpj.2017.29 WOS Scopus РИНЦ
Файлы: Полный текст от издателя
Даты:
Опубликована в печати: 3 окт. 2017 г.
Идентификаторы:
Web of science WOS:000417369600030
Scopus 2-s2.0-85031402849
РИНЦ 31101672
OpenAlex W2763292560
Альметрики: