Synthesis of 1,5,6,7-Tetrahydro-4H- benzimidazol-4-one Derivatives from 2,6-Bis(hydroxyimino)cyclohexan-1-one

Synthesis of 1,5,6,7-Tetrahydro-4H- benzimidazol-4-one Derivatives from 2,6-Bis(hydroxyimino)cyclohexan-1-one Full article

Journal

Russian Journal of Organic Chemistry
ISSN: 1070-4280 , E-ISSN: 1608-3393

Output data

Year: 2017, Volume: 53, Number: 1, Pages: 66-73 Pages count : 8 DOI: 10.1134/S1070428017010122

Authors

Samsonov V.A. ¹

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Pr Akad Lavrenteva 9, Novosibirsk 630090, Russia

The reaction of 2,6-bis(hydroxyimino)cyclohexan-1-one with aldehydes and ammonia afforded 2-substituted 4-hydroxyimino-4,5,6,7-tetrahydro-1H-benzimidazol-1-ols which were hydrolyzed to 1-hydroxy2- R-1,5,6,7-tetrahydro-4H-benzimidazol-4-ones. The N-hydroxy group in the latter can readily by removed by the action of chloroacetone in the presence of a base (potassium carbonate or triethylamine); as a result, 2-substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones were obtained.

Samsonov V.A.
Synthesis of 1,5,6,7-Tetrahydro-4H- benzimidazol-4-one Derivatives from 2,6-Bis(hydroxyimino)cyclohexan-1-one
Russian Journal of Organic Chemistry. 2017. V.53. N1. P.66-73. DOI: 10.1134/S1070428017010122 WOS Scopus РИНЦ

Самсонов В.А.
Синтез производных 1,5,6,7-тетрагидро- 4н-бензимидазол-4-она на основе 2,6- бис(гидроксиимино)циклогексан-1 -она
Журнал органической химии (RUSS J ORG CHEM+). 2017. Т.53. №1. С.71-77. РИНЦ

Published print:	Jan 1, 2017
Published online:	Mar 8, 2017

Web of science	WOS:000396525200012
Scopus	2-s2.0-85014865828
Elibrary	29488922
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